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Titolo:
ALTERATIONS IN ULTRASTRUCTURAL-LOCALIZATION OF GROWTH-ASSOCIATED PROTEIN-43 (GAP-43) IN PERIODONTAL RUFFINI ENDINGS OF RAT MOLARS DURING EXPERIMENTAL TOOTH MOVEMENT
Autore:
KOBAYASHI H; OCHI K; SAITO I; HANADA K; MAEDA T;
Indirizzi:
NIIGATA UNIV,SCH DENT,DEPT ORTHODONT,2-5274 GAKKOCHO DORI NIIGATA 9518514 JAPAN NIIGATA UNIV,SCH DENT,DEPT ORTHODONT NIIGATA 9518514 JAPAN NIIGATA UNIV,SCH DENT,DEPT ORAL ANAT NIIGATA 9518514 JAPAN
Titolo Testata:
Journal of dental research
fascicolo: 3, volume: 77, anno: 1998,
pagine: 503 - 517
SICI:
0022-0345(1998)77:3<503:AIUOGP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NERVOUS-SYSTEM; KINASE-C SUBSTRATE; SCHWANN-CELLS; NEUROFILAMENT PROTEIN; POSTNATAL-DEVELOPMENT; AXONAL REGENERATION; SENSORY RECEPTORS; PGP-9.5 ANTIBODY; S-100 PROTEIN; DENTAL-PULP;
Keywords:
GAP-43; RUFFINI ENDING; SCHWANN CELL; AXON TERMINAL; TOOTH MOVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
H. Kobayashi et al., "ALTERATIONS IN ULTRASTRUCTURAL-LOCALIZATION OF GROWTH-ASSOCIATED PROTEIN-43 (GAP-43) IN PERIODONTAL RUFFINI ENDINGS OF RAT MOLARS DURING EXPERIMENTAL TOOTH MOVEMENT", Journal of dental research, 77(3), 1998, pp. 503-517

Abstract

It is known that orthodontic forces induce discomfort and/or abnormalsensation after application of an orthodontic appliance in patients, suggesting the adaptation of periodontal neural elements to environmental changes. However, no morphological data have been provided. The present study investigated, by immunoelectron microscopy, the localization of growth-associated protein-43 (GAP-43) in periodontal Ruffini endings in rat molars during experimental tooth movement. In the untreated control group, immunoelectron microscopy demonstrated that GAP-43-like immunoreactivity in the Ruffini endings was confined to the Schwannsheaths around the axon terminals, and was in neither the cell bodiesof terminal Schwann cells nor the axon terminals themselves. Immunoelectron microscopic observation revealed alterations in the localization of GAP-43-like immunoreactivity in the periodontal Ruffini endings during experimental tooth movement. After 1 day of treatment, the cell bodies of the terminal Schwann cells associated with Ruffini endings appeared to contain immunoreaction products for GAP-43, and retained GAP-43-like immunoreactivity during tooth movement. From 5 to 7 days, a major population of the axoplasm of the periodontal Ruffini endings, which was immunonegative in control, filled the GAP-43 immunoreactions,showing a tendency to decrease in number later, and disappeared completely at 14 days. These findings suggest that orthodontic forces easily induce the remodeling of the mechanoreceptive Ruffini endings as well as the active tissue remodeling in a close relationship. Since the ultrastructural localization of GAP-43-like immunoreactivity was drastically changed in the Ruffini endings during tooth movement, GAP-43 functions as one of the key molecules in the remodeling of mechanoreceptive Ruffini endings during tooth movement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 09:24:09