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Titolo:
EFFECTS OF RISPERIDONE AND HALOPERIDOL ON TACHYKININ AND OPIOID PRECURSOR PEPTIDE MESSENGER-RNA LEVELS IN THE CAUDATE-PUTAMEN AND NUCLEUS-ACCUMBENS OF THE RAT
Autore:
MIJNSTER MJ; SCHOTTE A; DOCTOR GJ; VOORN P;
Indirizzi:
VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,GRAD SCH NEUROSCI AMSTERDAM,RES INST NEUROSCI NL-1081 BT AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,GRAD SCH NEUROSCI AMSTERDAM,RES INST NEUROSCI NL-1081 BT AMSTERDAM NETHERLANDS JANSSEN RES FDN,DEPT BIOCHEM PHARMACOL B-2340 BEERSE BELGIUM
Titolo Testata:
Synapse
fascicolo: 4, volume: 28, anno: 1998,
pagine: 302 - 312
SICI:
0887-4476(1998)28:4<302:EORAHO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; ATYPICAL NEUROLEPTIC TREATMENT; BASAL GANGLIA; SUBSTANCE-P; ANTIPSYCHOTIC-DRUGS; GENE-EXPRESSION; 6-HYDROXYDOPAMINE LESIONS; DOPAMINERGIC REGULATION; STRIATONIGRAL PATHWAY; TARDIVE-DYSKINESIA;
Keywords:
ANTIPSYCHOTIC DRUGS; IN SITU HYBRIDIZATION; ENKEPHALIN; DYNORPHIN; SUBSTANCE P; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mijnster et al., "EFFECTS OF RISPERIDONE AND HALOPERIDOL ON TACHYKININ AND OPIOID PRECURSOR PEPTIDE MESSENGER-RNA LEVELS IN THE CAUDATE-PUTAMEN AND NUCLEUS-ACCUMBENS OF THE RAT", Synapse, 28(4), 1998, pp. 302-312

Abstract

We investigated whether the two output pathways of the striatum are differently affected by the novel atypical drug risperidone and the conventional typical antipsychotic drug haloperidol, To this end, changesin mRNA levels of preproenkephalin-A, preproenkephalin-B, and preprotachykinin were determined in the rat striatum following chronic drug treatment for 14 days, using quantitative in situ hybridization. Furthermore, we studied the contribution of the dopamine D-2 and serotonin 5-HT2A antagonist components of risperidone in establishing its effectson neuropeptide mRNA levels in the striatum. The results showed that both risperidone and haloperidol had major effects on the preproenkephalin-A mRNA and thus on the indirect striatal output route, whereas they had minor effects on preproenkephalin-B and preprotachykinin mRNA, contained by the direct output route. When both drugs were administered in the same dose, preproenkephalin-A mRNA was much more elevated by haloperidol than by risperidone. However: when doses of risperidone and haloperidol were modified to attain comparable dopamine D-2 receptoroccupancy the drugs had comparable effects on preproenkephalin-A mRNAlevels. It was further found that 5-HT2A/C receptor blockade with ritanserin had only modest effects on preproenkephalin-B and preprotachykinin mRNA levels and did not affect preproenkephalin-A mRNA levels, Weconclude that risperidone and haloperidol, administered in the same dose, differently affect the striatal output routes. Furthermore, the results suggest that the effects of risperidone on neuropeptide mRNA levels are fully accounted for by its D-2 antagonism and that no indication exists for a role of 5-HT2A receptor blockade in this action. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:26:09