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Titolo:
SYNAPSE-SPECIFIC ACCUMULATION OF LITHIUM IN INTRACELLULAR MICRODOMAINS - A MODEL FOR UNCOUPLING COINCIDENCE DETECTION IN THE BRAIN
Autore:
KABAKOV AY; KARKANIAS NB; LENOX RH; PAPKE RL;
Indirizzi:
UNIV FLORIDA,COLL MED,J HILLIS MILLER HLTH CTR,DEPT PHARMACOL & TOXICOL,POB 100267 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,J HILLIS MILLER HLTH CTR,DEPT PHARMACOL & TOXICOL GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,J HILLIS MILLER HLTH CTR,DEPT PSYCHIAT GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,J HILLIS MILLER HLTH CTR,DEPT NEUROSCI GAINESVILLE FL 32610
Titolo Testata:
Synapse
fascicolo: 4, volume: 28, anno: 1998,
pagine: 271 - 279
SICI:
0887-4476(1998)28:4<271:SAOLII>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR DISORDER; CYCLIC-AMP; RAT-BRAIN; TRANSMISSION; RECEPTORS; CELLS; ION;
Keywords:
BIPOLAR DISORDER; GLUTAMATE RECEPTOR; DENDRITIC SPINE; ION DIFFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A.Y. Kabakov et al., "SYNAPSE-SPECIFIC ACCUMULATION OF LITHIUM IN INTRACELLULAR MICRODOMAINS - A MODEL FOR UNCOUPLING COINCIDENCE DETECTION IN THE BRAIN", Synapse, 28(4), 1998, pp. 271-279

Abstract

Lithium's therapeutic specificity for the treatment of bipolar disorder may be attributable in part to an ability to target sites where there are high levels of synaptic activity. We show that glutamate receptors expressed in oocytes are highly permeable to lithium. Mathematicalsimulations of Li+ diffusion in mature dendritic spines suggest that in the presence of 1 mM extracellular lithium one synaptic current canincrease Li+ concentration in the spine head by 4 mM with a decay time constant of about 15-20 ms. Two or more current spikes will produce oscillations between 6 and 8 mM or potentially higher. These results predict that the local intracellular lithium in dendritic spines can rise to high enough levels to uncouple second messenger mechanisms of coincidence detection. (C) 1998 WiIey-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:30:57