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Titolo:
LACTATED RINGERS SOLUTION RESUSCITATION CAUSES NEUTROPHIL ACTIVATION AFTER HEMORRHAGIC-SHOCK
Autore:
RHEE P; BURRIS D; KAUFMANN C; PIKOULIS M; AUSTIN B; LING G; HARVIEL D; WAXMAN K;
Indirizzi:
UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD BETHESDA MD 20814 WASHINGTON HOSP CTR,DEPT SURG WASHINGTON DC 20010 SANTA BARBARA COTTAGE HOSP,DEPT SURG SANTA BARBARA CA 00000
Titolo Testata:
The journal of trauma, injury, infection, and critical care
fascicolo: 2, volume: 44, anno: 1998,
pagine: 313 - 319
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYPERTONIC SALINE RESUSCITATION; SUPEROXIDE ANION PRODUCTION; MULTIPLE ORGAN FAILURE; OXIDATIVE BURST; WHOLE-BLOOD; INJURY; SEQUESTRATION; PHAGOCYTOSIS; LEUKOCYTES;
Keywords:
NEUTROPHILS; ACTIVATION; SWINE; HEMORRHAGE; SHOCK; RESUSCITATION; LACTATED RINGERS SOLUTION; HYPERTONIC SALINE; FLOW CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P. Rhee et al., "LACTATED RINGERS SOLUTION RESUSCITATION CAUSES NEUTROPHIL ACTIVATION AFTER HEMORRHAGIC-SHOCK", The journal of trauma, injury, infection, and critical care, 44(2), 1998, pp. 313-319

Abstract

Purpose: To determine the degree of neutrophil activation caused by hemorrhagic shock and resuscitation. Methods: Awake swine underwent 15-minute 40% blood volume hemorrhage, and a 1-hour shock period, followed by resuscitation with: group I, lactated Ringer's solution (LR); group II, shed blood; and group III, 7.5% hypertonic saline (HTS). Group TV underwent sham hemorrhage and LR infusion. Neutrophil activation was measured in whole blood using flow cytometry to detect intracellularsuperoxide burst activity. Results: Neutrophil activation increased significantly immediately after hemorrhage, but it was greatest after resuscitation with LR (group I, 273 vs, 102%; p < 0.05). Animals that received shed blood (group II) and HTS (group III) had neutrophil activity return to baseline state after resuscitation. Group IV animals hadan increase in neutrophil activation (259 vs. 129%; p < 0.05). Conclusion: Neutrophil activation occurring after LR resuscitation and LR infusion without hemorrhage, but not after resuscitation with shed bloodor HTS, suggests that the neutrophil activation may be caused by LR and not by reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:57:09