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Titolo:
MATHEMATICAL CONSIDERATIONS FOR MODELING CEREBRAL BLOOD-FLOW AUTOREGULATION TO SYSTEMIC ARTERIAL-PRESSURE
Autore:
GAO EZ; YOUNG WL; PILESPELLMAN J; ORNSTEIN E; MA QY;
Indirizzi:
COLUMBIA UNIV,DEPT ELECT ENGN NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT ANESTHESIOL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL SURG NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIOL NEW YORK NY 10032
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 43, anno: 1998,
pagine: 1023 - 1031
SICI:
0363-6135(1998)43:3<1023:MCFMCB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CONVERTING ENZYME-INHIBITION; AUTO-REGULATION; BRAIN-BARRIER; UPPER LIMIT; CIRCULATION; HYPOTENSION; CALIBER; DOGS; VALIDATION;
Keywords:
CEREBRAL HEMODYNAMICS; CEREBRAL CIRCULATION; LIMITS OF AUTOREGULATION; COMPARTMENTAL FLOW MODEL; SIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E.Z. Gao et al., "MATHEMATICAL CONSIDERATIONS FOR MODELING CEREBRAL BLOOD-FLOW AUTOREGULATION TO SYSTEMIC ARTERIAL-PRESSURE", American journal of physiology. Heart and circulatory physiology, 43(3), 1998, pp. 1023-1031

Abstract

The shape of the autoregulation curve for cerebral blood flow (CBF) vs. pressure is depicted in a variety of ways to fit experimentally derived data. However, there is no general empirical description to reproduce CBF changes resulting from systemic arterial pressure variations that is consistent with the reported data. We analyzed previously reported experimental data used to construct autoregulation curves. To improve on existing portrayals of the fitting of the observed data, a compartmental model was developed for synthesis of the autoregulation curve. The resistive arterial and arteriolar network was simplified as anautoregulation device (ARD), which consists of four compartments in series controlling CBF. Each compartment consists of a group of identical vessels in parallel. The response of each vessel category to changes in perfusion pressure was simulated using reported experimental data. The CBF-pressure curve was calculated from the resistance of the ARD. The predicted autoregulation curve was consistent with reported experimental data. The lower and upper Limits of autoregulation (LLA and ULA) were predicted as 69 and 153 mmHg, respectively. The average valueof the slope of the CBF-pressure curve below LLA and beyond ULA was predicted as 1.3 and 3.3% change in CBF per mmHg, respectively. Our four-compartment ARD model, which simulated small arteries and arterioles, predicted an autoregulation function similar to experimental data with respect to the LLA, ULA, and average slopes of the autoregulation curve below LLA and above ULA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 22:43:47