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Titolo:
LEFT-VENTRICULAR DIASTOLIC FUNCTION OF REMODELED MYOCARDIUM IN DOGS WITH PACING-INDUCED HEART-FAILURE
Autore:
SOLOMON SB; NIKOLIC SD; GLANTZ SA; YELLIN EL;
Indirizzi:
UNIV CALIF SAN FRANCISCO,INST CARDIOVASC RES,505 PARNASSUS AVE,BOX 0124 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 94143 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT CARDIOTHORAC SURG BRONX NY10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PHYSIOL & BIOPHYS BRONX NY10461 STANFORD UNIV,SCH MED,PALO ALTO MED FDN,RES INST,DEPT CARDIOVASC & THORAC SURG PALO ALTO CA 94306
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 43, anno: 1998,
pagine: 945 - 954
SICI:
0363-6135(1998)43:3<945:LDFORM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE LEFT-VENTRICLE; SUPRAVENTRICULAR TACHYCARDIA; DOPPLER ECHOCARDIOGRAPHY; DILATED CARDIOMYOPATHY; CONDUCTANCE CATHETER; FILLING DYNAMICS; PRESSURE; VOLUME; RELAXATION; STIFFNESS;
Keywords:
CARDIAC MECHANICS; RESTRICTIVE PATTERN OF FILLING; ELASTIC RECOIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Solomon et al., "LEFT-VENTRICULAR DIASTOLIC FUNCTION OF REMODELED MYOCARDIUM IN DOGS WITH PACING-INDUCED HEART-FAILURE", American journal of physiology. Heart and circulatory physiology, 43(3), 1998, pp. 945-954

Abstract

In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties ofthe myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate filling during pacing-induced heart failure in the anesthetized dog. Elastic properties of the myocardium were determined by analyzing the myocardial stress-strain relation. Left ventricular chamber properties were determined by analyzing the pressure-volume relation using a logarithmic approach. Elastic recoil was characterized using a computer-controlled mitral valve occluder to prevent transmitral flow during diastole. We conclude that, during heart failure, the high end-diastolic pressures suggestive of a stiff ventricle are due not to stiffer myocardium but to a ventricle whose chamber compliance characteristics are changed due to geometric remodeling of the myocardium. The restrictive filling pattern is a result of the ventricle being forced to operate on the stiff portion of thediastolic pressure-volume relation to maintain cardiac output. Slowedrelaxation and decreased contractility result in an inability of the heart to contract to an end-systolic volume below its diastolic equilibrium volume. Thus the left ventricle cannot utilize elastic recoil tofacilitate filling during heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:00:46