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Titolo:
HEMOSTATIC FACTORS IN RABBIT LIMB LYMPH - RELATIONSHIP TO MECHANISMS REGULATING EXTRAVASCULAR COAGULATION
Autore:
LE DT; BORGS P; TONEFF TW; WITTE MH; RAPAPORT SI;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT PATHOL,9500 GILMAN DR LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT MED LA JOLLA CA 92093 UNIV ARIZONA,HLTH SCI CTR,SECT GEN SURG & TRAUMA TUCSON AZ 85924
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 43, anno: 1998,
pagine: 769 - 776
SICI:
0363-6135(1998)43:3<769:HFIRLL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR PATHWAY INHIBITOR; TISSUE FACTOR; FACTOR-X; CELL-SURFACES; FACTOR-VII; FACTOR-IX; ACTIVATION; PLASMA; PURIFICATION; ANTITHROMBIN;
Keywords:
FACTOR V; FACTOR VIII; TISSUE FACTOR PATHWAY INHIBITOR; VON WILLEBRAND FACTOR; ANTITHROMBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Le et al., "HEMOSTATIC FACTORS IN RABBIT LIMB LYMPH - RELATIONSHIP TO MECHANISMS REGULATING EXTRAVASCULAR COAGULATION", American journal of physiology. Heart and circulatory physiology, 43(3), 1998, pp. 769-776

Abstract

Mechanisms regulating extravascular coagulation in interstitial fluids of peripheral tissues are poorly understood, since measurements of hemostatic factors in these fluids are unavailable. Because lymph from a body region reflects the composition of its interstitial fluid, we measured hemostatic factors in limb lymph of rabbits both as activity and as antigen. Mean lymph-to-plasma activity ratios were the following: fibrinogen, 0.28; prothrombin, 0.26; factor X, 0.27; factor VII, 0.17; and factors V and VIII, 0.08. All lymph fibrinogen was clottable; fibrin degradation products were absent. Lymph von Willebrand factor antigen was <10% of plasma antigen and consisted primarily of lower molecular weight multimers. Mean lymph-to-plasma activity ratio for antithrombin was 0.38 and for tissue factor pathway inhibitor the ratio was 0.40. Low levels of antithrombin-factor Xa were measurable in lymph. The data are compatible with a basal factor VIIa-tissue factor-catalyzed extravascular activation of factor X that is prevented from progressing to generation of fibrin in limb interstitial fluid and lymph by low levels of factor VIII and factor V and by the inhibitory activity ofantithrombin and tissue factor pathway inhibitor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:31:20