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Titolo:
THYROID-C CELLS OF MIDDLE-AGED RATS TREATED WITH ESTRADIOL OR CALCIUM
Autore:
SEKULIC M; LOVREN M; MILOSEVIC V; MICIC M; BALINTPERIC L;
Indirizzi:
INST BIOL RES DR SINISA STANKOVIC,29 NOVEMBRA 142 YU-11060 BELGRADE YUGOSLAVIA IMMUNOL RES CTR BRANISLAV JANKOVIC BELGRADE YUGOSLAVIA UNIV BELGRADE,MED CTR ZVEZDARA,DEPT ENDOCRINOL BELGRADE YUGOSLAVIA
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 3, volume: 109, anno: 1998,
pagine: 257 - 262
SICI:
0948-6143(1998)109:3<257:TCOMRT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIMINISHED CALCITONIN SECRETION; PARAFOLLICULAR CELLS; OVARIECTOMIZED RATS; ESTROGEN-RECEPTORS; PLASMA CALCITONIN; GONADAL-STEROIDS; 17-BETA-ESTRADIOL; CARCINOMA; HYPERCALCEMIA; REPLACEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Sekulic et al., "THYROID-C CELLS OF MIDDLE-AGED RATS TREATED WITH ESTRADIOL OR CALCIUM", HISTOCHEM C, 109(3), 1998, pp. 257-262

Abstract

The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) ora combination of EDP+Ca were studied. A stereological method was usedto determine the volume of calcitonin (CT)-immunoreactive C cells andtheir nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number ofC cells per section, in comparison with the corresponding controls. Areduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP-and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, wereseen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.

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Documento generato il 02/07/20 alle ore 22:33:27