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Titolo:
METABOLITES PRODUCED DURING THE PEROXISOMAL BETA-OXIDATION OF LINOLEATE AND ARACHIDONATE MOVE TO MICROSOMES FOR CONVERSION BACK TO LINOLEATE
Autore:
LUTHRIA DL; CHEN Q; SPRECHER H;
Indirizzi:
OHIO STATE UNIV,DEPT MED BIOCHEM,337 HAMILTON HALL,1645 NEIL AVE COLUMBUS OH 43210 OHIO STATE UNIV,DEPT MED BIOCHEM COLUMBUS OH 43210
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 233, anno: 1997,
pagine: 438 - 441
SICI:
0006-291X(1997)233:2<438:MPDTPB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNSATURATED FATTY-ACIDS; HUMAN SKIN FIBROBLASTS; DELTA(3,5),DELTA(2,4)-DIENOYL-COA ISOMERASE; CHAIN ELONGATION; RAT; RETROCONVERSION; REDUCTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Luthria et al., "METABOLITES PRODUCED DURING THE PEROXISOMAL BETA-OXIDATION OF LINOLEATE AND ARACHIDONATE MOVE TO MICROSOMES FOR CONVERSION BACK TO LINOLEATE", Biochemical and biophysical research communications, 233(2), 1997, pp. 438-441

Abstract

When [1-C-14]4,7,10-16:3, a product produced after two cycles of arachidonate beta-oxidation, was incubated with rat liver peroxisomes and microsomes it was metabolized to 2-trans-4,7,10-16:4, a catabolic product; 6,9,12-18:3 and 8,11,14-20:3, anabolic products made via microsomal chain elongation of the substrate; and 7,10-16:2 and 9,12-18:2, Analysis of the acyl-CoAs produced when 6,9,12-18:3 and its catabolic product, 4,7,10-16:3, where incubated under the above conditions showed that the acyl-CoAs of all of the above compounds, as well as 5,8-14:2-CoA and 6:0-CoA accumulated, Our results show that when 5,8-14:2 and 4,7,10-16:3 are produced by peroxisomal beta-oxidation they can be further degraded to hexanoyl-CoA or move to microsomes for conversion back to linoleate, which is a precursor of arachidonate. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:15:01