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Titolo:
THE ROLE OF THE DRUG EXCIPIENT PARTICLE-SIZE RATIO IN THE PERCOLATIONMODEL FOR TABLETS/
Autore:
MILLAN M; CARABALLO I; RABASCO AM;
Indirizzi:
UNIV SEVILLE,FAC PHARM & PHARMACEUT TECHNOL E-41012 SEVILLE SPAIN UNIV SEVILLE,FAC PHARM & PHARMACEUT TECHNOL E-41012 SEVILLE SPAIN
Titolo Testata:
Pharmaceutical research
fascicolo: 2, volume: 15, anno: 1998,
pagine: 216 - 220
SICI:
0724-8741(1998)15:2<216:TROTDE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX TABLETS; SYSTEMS;
Keywords:
PERCOLATION THEORY; PERCOLATION THRESHOLD; INERT MATRIX TABLETS; CONTROLLED RELEASE; DRUG/EXCIPIENT PARTICLE SIZE RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Millan et al., "THE ROLE OF THE DRUG EXCIPIENT PARTICLE-SIZE RATIO IN THE PERCOLATIONMODEL FOR TABLETS/", Pharmaceutical research, 15(2), 1998, pp. 216-220

Abstract

Purpose. In previous papers, a linear relationship between drug particle size and drug percolation threshold was found in inert matrix tablets. The main objectives of the present work are: to study the influence of the excipient particle size on the drug percolation threshold and to investigate if the change in the drug percolation threshold is due either to the absolute or to the relative drug particle size. Methods. Matrix tablets have been prepared using KCI (7 different particle size fractions) as a drug model and Eudragit(R) RS-PM (4 granulommetricfractions) as matrix forming material. In vitro release assays were carried out on the 66 lots of tablets. The drug percolation thresholds were estimated following the method of Bonny and Leuenberger. Results,The particle size of the excipient has shown an opposite effect to the drug size on the drug percolation threshold. Nevertheless, the influence of drug and excipient sizes on the drug percolation threshold areof the same magnitude. Conclusions. The drug percolation threshold depends linearly on the relative drug particle size. This finding is in agreement with percolation theory and can facilitate the use of the percolation threshold as a preformulation parameter to improve the pharmaceutical dosage forms design.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:37:23