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Titolo:
COMPARATIVE-STUDY OF THE DIALYZABILITY OF IOBITRIDOL AND IOHEXOL IN THE RAT WITH IMPAIRED RENAL-FUNCTION
Autore:
DENCAUSSE A; CHAMBON C; VIOLAS X; BONNEMAIN B;
Indirizzi:
LAB GUERBET,BP 50400 F-95943 ROISSY FRANCE
Titolo Testata:
Acta radiologica
fascicolo: 5, volume: 36, anno: 1995,
pagine: 545 - 548
SICI:
0284-1851(1995)36:5<545:COTDOI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST-MEDIUM; FAILURE; PHARMACOKINETICS; CLEARANCE; IOPAMIDOL;
Keywords:
CONTRAST MEDIA, IOBITRIDOL; IOHEXOL; DIALYZABILITY; EXPERIMENTAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Dencausse et al., "COMPARATIVE-STUDY OF THE DIALYZABILITY OF IOBITRIDOL AND IOHEXOL IN THE RAT WITH IMPAIRED RENAL-FUNCTION", Acta radiologica, 36(5), 1995, pp. 545-548

Abstract

Purpose: To assess the dialysability of iobitridol, a comparative study with iohexol was conducted in the rat over 4 hours. Material and Methods: After ligature of the renal Veins and arteries, a group of animals was submitted to continuous peritoneal dialysis, while the remainder were not. Results: In the event of total renal failure, biliary excretion rose from 0.4 to 9% for iobitridol and from 2 to 16% for iohexol. In the rats submitted to peritoneal dialysis, biliary excretion decreased to 5% in the iobitridol group and to 13% in the iohexol group. Further, 18% of the test substances were eliminated in the dialysis liquid. Conclusions. As their physicochemical characteristics are very similar, the differences between the biliary excretion levels of these 2 media may be caused by a factor related to their respective molecular conformations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:37:28