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Titolo:
EFFECTS OF SOME BETA-ADRENERGIC BLOCKERS ON MALE-FERTILITY PARAMETERSIN RATS
Autore:
ELSAYED MGA; ELSAYED MT; ELAZAB A; HAFEIZ MH; ELKOMY AAA; HASSAN E;
Indirizzi:
FAC VET MED,DEPT PHARMACOL BANHA MOSHTOHOR EGYPT FAC VET MED,DEPT GYNECOL BANHA MOSHTOHOR EGYPT ZAGAZIG UNIV,FAC VET MED ZAGAZIG EGYPT
Titolo Testata:
DTW. Deutsche tierarztliche Wochenschrift
fascicolo: 1, volume: 105, anno: 1998,
pagine: 10 - 12
SICI:
0341-6593(1998)105:1<10:EOSBBO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGINA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.G.A. Elsayed et al., "EFFECTS OF SOME BETA-ADRENERGIC BLOCKERS ON MALE-FERTILITY PARAMETERSIN RATS", DTW. Deutsche tierarztliche Wochenschrift, 105(1), 1998, pp. 10-12

Abstract

The effects of atenolol (9 and 18 mg/kg.b.wt.), metoprolol (3.5 and 7mg/kg.b.wt.) and propranolol (7.5 and 15 mg/kg.b.wt.) on male rate fertility were investigated following repeated oral administrations for 60 consecutive days. Repeated administrations of atenolol (9 and 18 mg/kg.b.wt.) induced non significant effects on weights of testes, epididymis and seminal vesicle at the first day, 30 and 60 days after the last repeated oral administration for 60 days. Administration of atenolol (9 and 18 mg/kg.b.wt.), metoprolol (3.5 and 7 mg/kg.b.wt.) and propranolol (15 mg/kg.b.wt.) to male rats induced significant decrease in percent of progressive motility of sperm at first day after the last oral administration for 60 days. Atenolol (18 mg/kg.b.wt.), metoprolol (7 mg/kg.b.wt.) and propranolol (7.5 and 15 mg/kg.b.wt.) induced significant increase in sperm head and tail abnormalities at first day after the last repeated dose. All rats treated with atenolol (9 mg/kg.b.wt.), metoprolol (7.5 and 15 mg/kg.b.wt.) and propranolol (7.5 and 15 mg/kg.b.wt.) induced significant decrease in the level of testosterone hormone at first and 30 days after the last dose. Repeated administrations of atenolol, metoprolol and propranolol in therapeutic and double therapeutic doses for 60 days induced nearly similar histopathologicalalterations in testis, epididymis and seminal vesicles. The induced hazard effects by the tested drugs on the male rat fertility were reversible as they returned to normal values 60 days after discontinuation of therapy.

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Documento generato il 25/01/20 alle ore 18:26:06