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Titolo:
EFFECTS OF DIHYDROLIPOIC ACID ON PEPTIDE METHIONINE SULFOXIDE REDUCTASE - IMPLICATIONS FOR ANTIOXIDANT DRUGS
Autore:
BIEWENGA GP; VEENINGGRIFFIOEN DH; NICASTIA AJ; HAENEN GRMM; BAST A;
Indirizzi:
FREE UNIV AMSTERDAM,FAC SCHEIKUNDE,LEIDEN AMSTERDAM CTR DRUG RES,DIV MOL PHARMACOL NL-1081 HV AMSTERDAM NETHERLANDS
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 2, volume: 48, anno: 1998,
pagine: 144 - 148
SICI:
0004-4172(1998)48:2<144:EODAOP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-LIPOIC ACID; OXIDIZED ALPHA-1-PROTEINASE INHIBITOR; INDUCED CATARACT FORMATION; ENZYMATIC REDUCTION; LIPID-PEROXIDATION; NEWBORN RATS; EXPRESSION; GENE; THIOREDOXIN; RESIDUES;
Keywords:
CAS 57828-26-9; ANTIOXIDANTS; ALPHA(1)-ANTIPROTEASE; DIHYDROLIPOIC ACID, ANTIOXIDATIVE EFFECT; LIPOIC ACID; PEPTIDE METHIONINE SULFOXIDE REDUCTASE; THIOCTACID(R);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G.P. Biewenga et al., "EFFECTS OF DIHYDROLIPOIC ACID ON PEPTIDE METHIONINE SULFOXIDE REDUCTASE - IMPLICATIONS FOR ANTIOXIDANT DRUGS", Arzneimittel-Forschung, 48(2), 1998, pp. 144-148

Abstract

By showing that dihydrolipoic acid (DHLA) reactivates oxidatively damaged alpha-1 antiprotease (alpha(1)-AP), a new antioxidant property ofDHLA is described. For the first time, it is shown that a drug is able to reverse oxidative damage of physiologically essential macromolecules. Until now, only antioxidant properties have been reported that prevent oxidative stress. Repair of oxidized alpha(1)-AP is catalysed bypeptide methionine sulfoxide reductase (PMSR, EC 1.8.4.6). It is found that DHLA acts as a reducing cofactor for PMSR. Oxidized alpha(1)-APhas been implicated in the etiology of certain lung diseases. Generally, by stimulating PMSR, DHLA may exert a curative effect in diseases accompanied by oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:55:17