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Titolo:
ILEAL-LYMPHOID-NODULAR HYPERPLASIA, NONSPECIFIC COLITIS, AND PERVASIVE DEVELOPMENTAL DISORDER IN CHILDREN
Autore:
WAKEFIELD AJ; MURCH SH; ANTHONY A; LINNELL J; CASSON DM; MALIK M; BERELOWITZ M; DHILLON AP; THOMSON MA; HARVEY P; VALENTINE A; DAVIES SE; WALKERSMITH JA;
Indirizzi:
UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT MED,INFLAMMATORY BOWEL DIS STUDY GRP LONDON NW3 2QG ENGLAND UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT HISTOPATHOL LONDON NW3 2QG ENGLAND UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT PAEDIAT GASTROENTEROL LONDONNW3 2QG ENGLAND UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT CHILD & ADOLESCENT PSYCHIAT LONDON NW3 2QG ENGLAND UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT NEUROL LONDON NW3 2QG ENGLAND UNIV LONDON ROYAL FREE HOSP,SCH MED,DEPT RADIOL LONDON NW3 2QG ENGLAND
Titolo Testata:
Lancet
fascicolo: 9103, volume: 351, anno: 1998,
pagine: 637 - 641
SICI:
0140-6736(1998)351:9103<637:IHNCAP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROHNS-DISEASE; AUTISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Wakefield et al., "ILEAL-LYMPHOID-NODULAR HYPERPLASIA, NONSPECIFIC COLITIS, AND PERVASIVE DEVELOPMENTAL DISORDER IN CHILDREN", Lancet, 351(9103), 1998, pp. 637-641

Abstract

Background We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder. Methods 12 children (mean age 6 years [range 3-10], 11 boys) were referred to a paediatric gastroenterology unit with a history of normal development followed by loss of acquired skills, including language, together with diarrhoea and abdominal pain. Children underwent gastroenterological, neurological, and developmental assessment and review of developmental records. Ileocolonoscopy and biopsy sampling, magnetic-resonance imaging (MRI), electroencephalography (EEG), and lumbar puncture were done under sedation. Barium follow-through radiography was done where possible. Biochemical, haematological, and immunological profiles were examined. Findings Onset of behavioural symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another. All 12 children had intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid ulceration. Histology showed patchy chronic inflammation in the colon in 11 children and reactive ileal lymphoid hyperplasia in seven, but no granulomas. Behavioural disorders included autism (nine), disintegrative psychosis (one), and possiblepostviral or vaccinal encephalitis (two). There were no focal neurological abnormalities and MRI and EEG tests were normal. Abnormal laboratory results were significantly raised urinary methylmalonic acid compared with age-matched controls (p=0.003), low haemoglobin in four children, and a low serum IgA in four children. Interpretation We identified associated gastrointestinal disease and developmental regression ina group of previously normal children, which was generally associatedin time with possible environmental triggers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:32:55