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Titolo:
ADRENOCORTICAL-RESPONSE AND REGIONAL T-LYMPHOCYTE ACTIVATION PATTERNSFOLLOWING MINIMALLY INVASIVE SURGERY IN A RAT MODEL
Autore:
BERGUER R; DALTON M; FERRICK D;
Indirizzi:
UNIV CALIF DAVIS,DEPT SURG,4301 X ST SACRAMENTO CA 95817 UNIV CALIF DAVIS,DEPT PATHOL MICROBIOL & IMMUNOL DAVIS CA 95616
Titolo Testata:
Surgical endoscopy
fascicolo: 3, volume: 12, anno: 1998,
pagine: 236 - 240
SICI:
0930-2794(1998)12:3<236:AARTAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LAPAROSCOPIC CHOLECYSTECTOMY; IMMUNE SUPPRESSION; SURGICAL STRESS; CELL ACTIVATION; PROLIFERATION; DISSOCIATION; MECHANISMS; EXPRESSION; HORMONES; SYSTEM;
Keywords:
LAPAROSCOPY; RATS; IMMUNE FUNCTION; LYMPHOCYTES; FLOW CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
R. Berguer et al., "ADRENOCORTICAL-RESPONSE AND REGIONAL T-LYMPHOCYTE ACTIVATION PATTERNSFOLLOWING MINIMALLY INVASIVE SURGERY IN A RAT MODEL", Surgical endoscopy, 12(3), 1998, pp. 236-240

Abstract

Background: Laparoscopic survey is associated with less tissue traumaand postoperative pain as well as a more rapid recovery than open surgery, We hypothesized that these factors may result in less immune impairment following laparoscopic surgery. Methods: We measured mitogen-induced surface interleukin-2 receptor (IL2R) expression and lymphocyteproliferation in CD4(+) and CD8(+) T-lymphocytes as well as serum corticosterone levels in rats 24 h following open (OP) and laparoscopic (LAP) fundoplication. Results: Serum corticosterone levels were lower in LAP vs OP rats (p = 0.02). CD4(+) IL2R expression was higher in the blood, but not in the spleen, in LAP vs OP animals (p = 0.02). CD8(+) IL2R expression was similar in both groups. Mitogen-induced lymphocyteproliferation was no different in the blood but decreased in the spleen in LAP vs OP rats (p = 0.03). Conclusions: Compared to open surgery, laparoscopic fundoplication in the rat results in lower adrenocortical hormone levels and better-preserved T-helper-cell activation in theblood. Lymphocyte proliferation is suppressed in the spleen 24 h after laparoscopic surgery. Minimally invasive surgery may better preservecell-mediated immunity in the early postoperative period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:28:03