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Titolo:
SEVERAL GABA(A) RECEPTOR SUBUNITS ARE EXPRESSED IN LHRH NEURONS OF JUVENILE FEMALE RATS
Autore:
JUNG H; SHANNON EM; FRITSCHY JM; OJEDA SR;
Indirizzi:
OREGON HLTH SCI UNIV,OREGON REG PRIMATE RES CTR,DIV NEUROSCI,505 NW 185TH AVE BEAVERTON OR 97006 OREGON HLTH SCI UNIV,OREGON REG PRIMATE RES CTR,DIV NEUROSCI BEAVERTON OR 97006 OREGON HLTH SCI UNIV,VOLLUM INST PORTLAND OR 97201 UNIV ZURICH,INST PHARMACOL CH-8057 ZURICH SWITZERLAND
Titolo Testata:
Brain research
fascicolo: 2, volume: 780, anno: 1998,
pagine: 218 - 229
SICI:
0006-8993(1998)780:2<218:SGRSAE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; GONADOTROPIN-RELEASING-HORMONE; HYPOTHALAMIC GT1-7 NEURONS; MESSENGER-RNAS; A RECEPTOR; GABA(A)-RECEPTOR SUBTYPES; SEXUAL-MATURATION; GABAERGIC CONTROL; RHESUS-MONKEYS; PREOPTIC AREA;
Keywords:
GABA(A) RECEPTOR; SEXUAL DEVELOPMENT; HYPOTHALAMUS; IN SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
H. Jung et al., "SEVERAL GABA(A) RECEPTOR SUBUNITS ARE EXPRESSED IN LHRH NEURONS OF JUVENILE FEMALE RATS", Brain research, 780(2), 1998, pp. 218-229

Abstract

Gamma aminobutyric acid (GABA), the dominant inhibitory neurotransmitter in brain, is involved in the developmental regulation of LHRH secretion. Morphological studies in rodents have demonstrated that LHRH neurons are innervated by GABA-containing processes, suggesting that LHRH secretion is under direct transsynaptic GABAergic control. While GABA acts through two different receptors, GABA(A) and GABA(B), to exert its effects, it appears that GABA(A) receptors are able to mediate both inhibitory and stimulatory effects of GABA on LHRH neurons. GABA(A) receptors are heterooligomeric ligand-gated anion channels that exhibit a diverse array of functional and pharmacological properties. This diversity is determined by the structural heterogeneity of the receptors, which are assembled from the combination of different classes of subunits with multiple isoforms. Although several studies have describedthe effect of GABA(A) receptor stimulation on LHRH and/or gonadotropin release in prepubertal animals, nothing is known about the receptor subunits that may be expressed in LHRH neurons at this phase in development. Double immunohistofluorescence followed by confocal laser microscopy revealed that subsets of prepubertal LHRH neurons are endowed with alpha(1), alpha(2), beta(2/3), and gamma(2) GABA(A) receptor subunits. Combined immunohistochemistry for LHRH neurons and in situ hybridization for GABA(A) subunit mRNAs confirmed that the genes encoding thealpha(1), alpha(2), beta(3) and gamma(2) subunits, but not the gamma(1) subunit, are expressed in LHRH neurons. Notwithstanding the relative insensitivity of these methods, both the immunohistochemical and hybridization histochemical approaches employed indicate that only a fraction of LHRH neurons are endowed with GABA(A) receptors. This arrangement suggests that those LHRH neurons bearing the appropriate GABA(A) receptors are responsible for either the entire secretory response to direct GABAergic inputs or for its initiation. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:13:05