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Titolo:
CALPAIN-MEDIATED PROTEOLYSIS OF GLUR1 SUBUNITS IN ORGANOTYPIC HIPPOCAMPAL CULTURES FOLLOWING KAINIC ACID TREATMENT
Autore:
BI XN; CHEN J; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM,HNB 309 LOS ANGELES CA 90089 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 781, anno: 1998,
pagine: 355 - 357
SICI:
0006-8993(1998)781:1-2<355:CPOGSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT BRAIN; SLICE CULTURES; KAINATE;
Keywords:
CALPAIN; HIPPOCAMPUS; GLUTAMATE RECEPTOR; SEIZURE; KAINATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
X.N. Bi et al., "CALPAIN-MEDIATED PROTEOLYSIS OF GLUR1 SUBUNITS IN ORGANOTYPIC HIPPOCAMPAL CULTURES FOLLOWING KAINIC ACID TREATMENT", Brain research, 781(1-2), 1998, pp. 355-357

Abstract

The present study examined changes in GluR1 subunits after kainic acid (KA) treatment of organotypic hippocampal cultures. Immunoblots labeled with antibodies directed at the C-terminal domain of GluR1 revealed a large decrease in GluR1 immunoreactivity at 6 h and 24 h, while immunoblots labeled with antibodies directed at the N-terminal domain indicated that KA treatment produced changes in structure but not amountof GluR1 protein. Changes in GluR1 subunits were significantly reduced by the calpain inhibitor, calpeptin. These results indicate that KA-induced changes in GluR1 properties are mediated by calpain activation. (C) 1998 Elsevier Science B.V.

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Documento generato il 26/01/21 alle ore 04:22:40