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Titolo:
DISINHIBITION OF RAT HIPPOCAMPAL PYRAMIDAL CELLS BY GABAERGIC AFFERENTS FROM THE SEPTUM
Autore:
TOTH K; FREUND TF; MILES R;
Indirizzi:
INST PASTEUR,NEUROBIOL CELLULAIRE LAB,25 RUE DR ROUX F-75724 PARIS 15FRANCE INST PASTEUR,NEUROBIOL CELLULAIRE LAB F-75724 PARIS 15 FRANCE HUNGARIAN ACAD SCI,INST EXPT MED H-1450 BUDAPEST HUNGARY
Titolo Testata:
Journal of physiology
fascicolo: 2, volume: 500, anno: 1997,
pagine: 463 - 474
SICI:
0022-3751(1997)500:2<463:DORHPC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHYTHMICAL SLOW ACTIVITY; THETA-RHYTHM; MEDIAL SEPTUM; INHIBITORY INTERNEURONS; NEURONS; FACILITATION; CA1; STIMULATION; MODULATION; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K. Toth et al., "DISINHIBITION OF RAT HIPPOCAMPAL PYRAMIDAL CELLS BY GABAERGIC AFFERENTS FROM THE SEPTUM", Journal of physiology, 500(2), 1997, pp. 463-474

Abstract

1. Slices were prepared from rat forebrain to include both the septumand the hippocampus in order to examine the effects of septal stimulation on hippocampal inhibitory circuits. 2. Repetitive stimulation of septo-hippocampal fibres caused a maintained decrease in the frequencyof spontaneous IPSPs recorded from CA3 pyramidal cells in the presence of antagonists of excitatory amino acid receptors and of muscarine receptors. 3. In records made from pyramidal cells with CsCl-filled electrodes, IPSPs were examined at potentials both more positive and morenegative than their reversal potential. Single septal stimuli hyperpolarized pyramidal cells when IPSPs were depolarizing events and depolarized them wiles IPSPs were hyperpolarizing. The GABA(A) receptor antagonist picrotoxin abolished the effects of septal stimulation. 4. Activation of septal afferents initiated an IPSP in hippocampal inhibitorycells but not in pyramidal cells. Septal IPSPs had similar kinetics to those initiated by local hippocampal stimulation and could suppress inhibitory cell discharge. 5. In pyramidal cells recorded with potassium acetate-filled electrodes, septal stimuli initiated a depolarization that increased with the driving force for Cl- and that could cause firing. 6. Rhythmic stimulation of septo-hippocampal fibres at 5 Hz initiated, in the hippocampus, a maintained out-of-phase oscillation of pyramidal cell discharge and inhibitory cell firing, as detected by theoccurrence of spontaneous IPSPs. 7. These results suggest that GABAergic septo-hippocampal afferents selectively inhibit hippocampal inhibitory cells and so disinhibit pyramidal cells. This disinhibition couldcontribute to the transmission of the theta rhythm from the septum tothe hippocampus.

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Documento generato il 05/04/20 alle ore 07:39:22