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Titolo:
ASSOCIATION BETWEEN THE GABA(A) RECEPTOR ALPHA(5) SUBUNIT GENE LOCUS (GABRA(5)) AND BIPOLAR AFFECTIVE-DISORDER
Autore:
PAPADIMITRIOU GN; DIKEOS DG; KARADIMA G; AVRAMOPOULOS D; DASKALOPOULOU EG; VASSILOPOULOS D; STEFANIS CN;
Indirizzi:
UNIV ATHENS,EGINIT HOSP,SCH MED,DEPT PSYCHIAT,CLIN & MOL NEUROGENET UNIT,72 VAS SOFIAS AVE GR-11528 ATHENS GREECE UNIV ATHENS,EGINIT HOSP,SCH MED,DEPT NEUROL GR-11528 ATHENS GREECE UNIV ATHENS,EGINIT HOSP,SCH MED,MENTAL HLTH RES INST GR-11528 ATHENS GREECE
Titolo Testata:
American journal of medical genetics
fascicolo: 1, volume: 81, anno: 1998,
pagine: 73 - 80
SICI:
0148-7299(1998)81:1<73:ABTGRA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANIC-DEPRESSIVE ILLNESS; GAMMA-AMINOBUTYRIC-ACID; PRADER-WILLI-SYNDROME; TYROSINE-HYDROXYLASE POLYMORPHISMS; X-CHROMOSOME MARKERS; PLASMA GABA; MONOAMINE-OXIDASE; ANGELMAN SYNDROME; CANDIDATE GENES; DNA MARKERS;
Keywords:
ASSOCIATION STUDY; GAMMA-AMINOBUTYRIC ACID (GABA); GABA-A RECEPTOR ALPHA-5 SUBUNIT GENE (GABRA5); CHROMOSOME 15; AFFECTIVE DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Papadimitriou et al., "ASSOCIATION BETWEEN THE GABA(A) RECEPTOR ALPHA(5) SUBUNIT GENE LOCUS (GABRA(5)) AND BIPOLAR AFFECTIVE-DISORDER", American journal of medical genetics, 81(1), 1998, pp. 73-80

Abstract

Genetic factors seem to play an important role in the pathogenesis ofaffective disorder, The candidate gene strategies are being used, among others, to identify the genes conferring vulnerability to the disease, The genes coding for the receptors of gamma-aminobutyric acid (GABA) have been proposed as candidates for affective disorder, since the GABA neurotransmitter system has been implicated in the pathogenesis of the illness, We examined the possible genetic association between the GABA(A) receptor alpha 5 subunit gene locus (GABRA5) on chromosome 15 and affective disorder, in 48 bipolar patients (BP), 40 unipolar patients (UP), and 50 healthy individuals, age-and sex-matched to the patients, All patients and controls were unrelated Greeks, Diagnoses weremade after direct interviews according to the DSM-IV and ICD-10 criteria, For the genotyping, a dinucleotide (CA) repeat marker was used, The polymerase chain reaction (PCR) products found were nine alleles with lengths between 272 and 290 base pairs (bp), The distribution of allelic frequencies of the GABRA5 locus differed significantly between BP patients and controls with the 282-bp allele found to be associated with BP affective disorder, while no such difference was observed between the groups of UP patients and controls nor between the two patientgroups, The presence or absence of the 282-bp allele in the genotype of BP patients was not shown to influence the age of onset and the overall clinical severity, but was found to be associated with a preponderance of manic over depressive episodes in the course of the illness, (C) 1998 Wiley-Liss, Inc.

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Documento generato il 05/07/20 alle ore 21:55:49