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Titolo:
TRYPTOPHAN-HYDROXYLASE GENOTYPE IS ASSOCIATED WITH IMPULSIVE-AGGRESSION MEASURES - A PRELIMINARY-STUDY
Autore:
NEW AS; GELERNTER J; YOVELL Y; TRESTMAN RL; NIELSEN DA; SILVERMAN J; MITROPOULOU V; SIEVER LJ;
Indirizzi:
BRONX VET ADM MED CTR,PSYCHIAT SERV 116A,130 W KINGSBRIDGE RD BRONX NY 10468 MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 00000 W HAVEN VA MED CTR,PSYCHIAT SERV 116A W HAVEN CT 00000 YALE UNIV,SCH MED,DEPT PSYCHIAT,DIV MOL PSYCHIAT NEW HAVEN CT 00000 NIAAA,NEUROGENET LAB,NIH ROCKVILLE MD 20852
Titolo Testata:
American journal of medical genetics
fascicolo: 1, volume: 81, anno: 1998,
pagine: 13 - 17
SICI:
0148-7299(1998)81:1<13:TGIAWI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; PERSONALITY-DISORDER; VIOLENT OFFENDERS; FIRE SETTERS; POLYMORPHISM; ALCOHOLISM; RFLP;
Keywords:
SEROTONIN; GENETICS; PERSONALITY DISORDERS; POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.S. New et al., "TRYPTOPHAN-HYDROXYLASE GENOTYPE IS ASSOCIATED WITH IMPULSIVE-AGGRESSION MEASURES - A PRELIMINARY-STUDY", American journal of medical genetics, 81(1), 1998, pp. 13-17

Abstract

To assess the relationship between two phenotypes in an extremely well-characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss-Durkee Hostility Inventory (BDHI). Twenty-one male patients with the ''LL'' genotype had higher BDHI scores than men with the ''UL'' or the ''UU'' genotype. No relationship between genotype andprolactin response to fenfluramine was found. It was concluded that impulsive-aggressive behavior in male personality disorder patients maybe associated with the TPH genotype. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:48:31