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Titolo:
COTRIMOXAZOLE DESENSITIZATION IN HIV-SEROPOSITIVE PATIENTS
Autore:
THEODORE CM; HOLMES D; RODGERS M; MCLEAN KA;
Indirizzi:
MAYDAY UNIV HOSP,DEPT GENITOURINARY MED,MAYDAY RD,THORNTON HEATH SURREY CR7 7YE ENGLAND CHARING CROSS HOSP,DEPT GENITOURINARY MED LONDON ENGLAND
Titolo Testata:
International journal of STD & AIDS
fascicolo: 3, volume: 9, anno: 1998,
pagine: 158 - 161
SICI:
0956-4624(1998)9:3<158:CDIHP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PNEUMOCYSTIS-CARINII PNEUMONIA; TRIMETHOPRIM-SULFAMETHOXAZOLE; INFECTED PATIENTS; AEROSOLIZED PENTAMIDINE; ADVERSE REACTIONS; CONTROLLED TRIAL; VIRUS INFECTION; PROPHYLAXIS;
Keywords:
HIV; COTRIMOXAZOLE; DESENSITIZATION; ADVERSE DRUG REACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Theodore et al., "COTRIMOXAZOLE DESENSITIZATION IN HIV-SEROPOSITIVE PATIENTS", International journal of STD & AIDS, 9(3), 1998, pp. 158-161

Abstract

Co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective prophylactic agent against Pneumocystis carinii pneumonia (PCP). However, it is associated with a high frequency of adverse reactions in immunocompromised patients which may preclude its use. Fourteen patients with a definite history of adverse reactions to co-trimoxazole on standard PCP prophylactic dosage were selected for desensitization using a regimen of gradual incremental exposure over an Ii-day period. Eight (57.1%) were successfully desensitized and have continued on oral co-trimoxazole at maximum 21 months' follow-up. This report demonstrates that oral desensitization as an outpatient procedure is an effective and safe option for both primary and secondary PCP prophylaxis in HIV-seropositive patients with previous adverse drug reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:51:09