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Titolo:
A SIMPLE METHOD OF PREPARATION FOR [I-I23]-(S)-(-)-IBZM
Autore:
WANG TST; MALASPINA D; VANHEERTUM RL;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT RADIOL,DIV NUCL MED NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PSYCHIAT NEW YORK NY 10032
Titolo Testata:
Applied radiation and isotopes
fascicolo: 4, volume: 49, anno: 1998,
pagine: 369 - 372
SICI:
0969-8043(1998)49:4<369:ASMOPF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IODINE-123-IBZM; RECEPTOR; DISEASE; BINDING; BRAIN; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
T.S.T. Wang et al., "A SIMPLE METHOD OF PREPARATION FOR [I-I23]-(S)-(-)-IBZM", Applied radiation and isotopes, 49(4), 1998, pp. 369-372

Abstract

Sterile, apyrogenic [I-123]IBZM was prepared in a sealed, capped 'V' vial, followed by SEP-PAK C-18 cartridge purification, and then was placed under sealed vial condensation. The quantity of BZM present in the final product ranged from 3.3-5.9 mu g, as measured by a UV spectrophotometer at 254 and 308 nm. Animal biodistribution studies revealed that the [I-123]IBZM prepared by this method which contained 5.9 mu g of BZM, compared to the standard preparation method containing 0 mu g of BZM, resulted in identical brain uptakes at 15, 30, 60, and 120 min post-injection. The in vitro and in vivo studies demonstrated that a small amount of BZM presence in the final product did not affect the radiochemical purity, nor the D-2 receptor binding capacity in the rat brain of [I-123]IBZM. The preparation time can be shortened to 1.5 h compared with at least 2-4 h needed for the standard method of preparation. This factor may be important in routine clinical application. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:07:38