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Titolo:
APOLIPOPROTEIN-E POLYMORPHISM IN ELDERLY EAST AFRICANS
Autore:
SAYI JG; PATEL NB; PREMKUMAR DRD; ADEM A; WINBLAD B; MATUJA WB; MTUI EP; GATERE S; FRIEDLAND RP; KOSS E; KALARIA RN;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT NEUROL SURG BRD5,10900 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,UH ALZHEIMER CTR CLEVELAND OH 44106 MUHIMBILI MED CTR,NEUROL UNIT DAR ES SALAAM TANZANIA HUDDINGE HOSP,DEPT CLIN NEUROSCI & FAMILY MED,GERIATR SECT S-14186 HUDDINGE SWEDEN AVE HOSP NAIROBI KENYA UNIV NAIROBI NAIROBI KENYA
Titolo Testata:
East African medical journal
fascicolo: 10, volume: 74, anno: 1997,
pagine: 668 - 670
SICI:
0012-835X(1997)74:10<668:APIEEA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; EPSILON-4 ALLELE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Sayi et al., "APOLIPOPROTEIN-E POLYMORPHISM IN ELDERLY EAST AFRICANS", East African medical journal, 74(10), 1997, pp. 668-670

Abstract

Current advances have shown the apolipoprotein E (APOE)-epsilon 4 allele to be highly associated with late-onset familial and sporadic Alzheimer's disease (AD) in Western populations, The association of APOE allele frequencies and dementia remain unknown in populations from developing countries, We recently initiated a project to examine APOE frequencies in nondemented and demented elderly East Africans. Blood DNA collected from two hospital-based populations showed that the APOE allele frequencies in a group of non-demented 67 Tanzanians over the age af 65 years were found to be 14% for epsilon 2, 61% for epsilon 3 and 25% for epsilon 4. By comparison, the frequency of APOE-epsilon 4 in anage-matched demented group was also 25%. Assessment of APOE genotypesin the group of elderly Kenyan subjects from Nairobi also revealed high frequencies of the epsilon 4 allele with no clear difference in frequency between demented and non-demented subjects. Our preliminary observations suggest that elderly East Africans with no apparent clinicalAD possess relatively high APOE-epsilon 4 allele frequencies comparedto normal ageing subjects from Western countries including Arican-Americans. These results appear similar to those reported in a recent study in Nigerian Africans where a lack of correlation between APOE-epsilon 4 allele frequency and Alzheimer type of dementia was noted, and imply that APOE-epsilon 4 allele may not necessarily he a risk factor insome populations of Africa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 10:47:36