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Titolo:
RHINOVIRUS-SPECIFIC T-CELLS RECOGNIZE BOTH SHARED AND SEROTYPE-RESTRICTED VIRAL EPITOPES
Autore:
GERN JE; DICK EC; KELLY EAB; VRTIS R; KLEIN B;
Indirizzi:
UNIV WISCONSIN HOSP,DEPT PEDIAT,600 HIGHLAND AVE,H4-438 MADISON WI 53792 UNIV WISCONSIN,SCH MED,DEPT PEDIAT MADISON WI 53706 UNIV WISCONSIN,SCH MED,DEPT PREVENT MED MADISON WI 53706 UNIV WISCONSIN,SCH MED,DEPT MED MADISON WI 53706
Titolo Testata:
The Journal of infectious diseases
fascicolo: 5, volume: 175, anno: 1997,
pagine: 1108 - 1114
SICI:
0022-1899(1997)175:5<1108:RTRBSA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; ASTHMATIC SUBJECTS; B-CELL; INFECTION; ANTIGEN; VIRUS; MICE; PRECIPITANTS; INFLAMMATION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Gern et al., "RHINOVIRUS-SPECIFIC T-CELLS RECOGNIZE BOTH SHARED AND SEROTYPE-RESTRICTED VIRAL EPITOPES", The Journal of infectious diseases, 175(5), 1997, pp. 1108-1114

Abstract

To characterize rhinovirus (RV)-specific T cells, RV16- and RV49-specific CD4 T cells were cloned from peripheral blood, and cytokine secretion and serotype specificity were defined. Each RV-specific clone secreted high levels of interferon-gamma, and several also produced interleukin-4 and -5. To test serotype specificity, each clone was incubated separately with five different RV serotypes. Although 2 of 31 clonesproliferated only in response to the virus used in cloning, the rest had significant proliferation in response to 2-5 different serotypes, Thus, RV-specific T cells can be activated by either serotype-specificor shared viral epitopes, raising the possibility that repeated activation of T cells by shared viral determinants in vivo could induce potent recall T cell responses. It is likely that enhanced T cell responses to shared viral epitopes contribute to antiviral activity, airway inflammation, or both.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 11:55:56