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Titolo:
EVOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE SEQUENCES IN INFECTED INDIVIDUALS WITH DIFFERING DISEASE PROGRESSION PROFILES
Autore:
SHANKARAPPA R; GUPTA P; LEARN GH; RODRIGO AG; RINALDO CR; GORRY MC; MULLINS JI; NARA PL; EHRLICH GD;
Indirizzi:
UNIV WASHINGTON,DEPT MICROBIOL,BOX 357740 SEATTLE WA 98195 UNIV PITTSBURGH,DEPT PATHOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT INFECT DIS & MICROBIOL PITTSBURGH PA 15261 BIOL MIMET INC FREDERICK MD 21701
Titolo Testata:
Virology
fascicolo: 2, volume: 241, anno: 1998,
pagine: 251 - 259
SICI:
0042-6822(1998)241:2<251:EOHTES>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; HIV-1 INFECTION; 1-INFECTED INDIVIDUALS; IMMUNE-RESPONSE; IN-VIVO; VARIANTS; AIDS; TRANSMISSION; LYMPHOCYTES; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
R. Shankarappa et al., "EVOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE SEQUENCES IN INFECTED INDIVIDUALS WITH DIFFERING DISEASE PROGRESSION PROFILES", Virology, 241(2), 1998, pp. 251-259

Abstract

Sequence Variation displayed by the human immunodeficiency virus type1 (HIV-1) has been proposed to be linked to the pathogenesis of acquired immunodeficiency syndrome (AIDS). To assess viral evolution duringthe course of infection, we evaluated sequence variability in the envvariable domains in four HIV-1-infected individuals exhibiting differing profiles of CD4(+) T cell decline when followed from seroconversion until the development of AIDS or loss of followup. Proviral sequences encoding the V3-V5 region of gp120 were obtained following PGR amplification of peripheral blood mononuclear cell DNA and cloning. Virus in each patient was relatively homogeneous early in infection and then diverged with time, more consistently at its nonsynonymous sites. Justprior to or coincident with a rapid decline in CD4(+) T cell numbers,sequences were found with basic amino acid substitutions clustered within and downstream of the gp120 V3 domain. Within the constraints of the current dataset, we conclude that the virus appears to continuallyaccumulate changes in its amino acid sequences well into the time of marked CD4(+) T cell decline. (C) 1998 Academic Press.

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Documento generato il 04/04/20 alle ore 20:43:37