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Titolo:
USE OF THE INTERNATIONAL PROGNOSTIC INDEX AND THE TUMOR SCORE TO DETECT POOR-RISK PATIENTS WITH PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA -A STUDY OF 37 PREVIOUSLY UNTREATED PATIENTS
Autore:
ROMAGUERA JE; DIAZPAVON JR; CARIAS L; HAGEMEISTER FB; MCLAUGHLIN P; RODRIGUEZ MA; SARRIS AH; YOUNES A; PRETI A; BACHIER C; LLERENA E; CABANILLAS F;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,LYMPHOMA SECT HOUSTON TX00000
Titolo Testata:
Leukemia & lymphoma
fascicolo: 3-4, volume: 28, anno: 1998,
pagine: 295 - 306
SICI:
1042-8194(1998)28:3-4<295:UOTIPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFUSE LARGE-CELL; NON-HODGKINS-LYMPHOMA; IMMUNOBLASTIC LYMPHOMA; LACTATE-DEHYDROGENASE; STAGING SYSTEM; MACOP-B; SCLEROSIS; CHEMOTHERAPY; PROPOSAL; SUBSET;
Keywords:
PRIMARY MEDIASTINAL LYMPHOMA; PROGNOSTIC MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Romaguera et al., "USE OF THE INTERNATIONAL PROGNOSTIC INDEX AND THE TUMOR SCORE TO DETECT POOR-RISK PATIENTS WITH PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA -A STUDY OF 37 PREVIOUSLY UNTREATED PATIENTS", Leukemia & lymphoma, 28(3-4), 1998, pp. 295-306

Abstract

We tested two prognostic models devised for intermediate-grade lymphomas, the age-adjusted international prognostic index and the tumor score, in 37 consecutive untreated patients treated for a diagnosis of primary mediastinal large El-cell lymphoma (PMLCL). Neither model selected for a group of patients with statistically significant differences in rates of complete response, failure-free survival (FFS) and overallsurvival (OS). Because the level of beta microglobulin (beta(2)m) is consistently low in the serum of patients with PMLCL, despite bulky disease, we tested the median value of this continuous variable in the 37 patients and found it to be statistically significant for predictingFFS. A hypothetical tumor score model using the adjusted value for beta(2)m improved the prognostic accuracy for achievement of complete response (93% vs. 60%; P = 0.02), FFS (73% vs, 35%; P = 0.02), and OS (80% vs. 55%; P = 0.05). This hypothetical model merits further testing in a larger population of patients with PMLCL.

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Documento generato il 14/07/20 alle ore 18:14:10