Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENTIAL-EFFECTS OF RANF AND CHRONIC GUANABENZ TO PRESYNAPTIC ANDPOSTSYNAPTIC ALPHA-2-ADRENOCEPTOR-MEDIATED CARDIOVASCULAR-RESPONSE INPITHED RATS
Autore:
SOHN UD; CHOI HC;
Indirizzi:
CHUNG ANG UNIV,COLL PHARM,DEPT PHARMACOL SEOUL 156756 SOUTH KOREA YEUNGNAM UNIV,SCH MED TAEGU 705035 SOUTH KOREA
Titolo Testata:
General pharmacology
fascicolo: 4, volume: 30, anno: 1998,
pagine: 605 - 611
SICI:
0306-3623(1998)30:4<605:DORACG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL NATRIURETIC PEPTIDE; VASCULAR SMOOTH-MUSCLE; EXTRACELLULAR CALCIUM; PRESSOR-RESPONSES; ALPHA-2; ADRENOCEPTORS; SYSTEM; PURIFICATION; ATRIOPEPTINS; STIMULATION;
Keywords:
PITHED RATS; GUANABENZ; RANF; BLOOD PRESSURE; HEART RATE; PRESYNAPTIC ALPHA-2-ADRENOCEPTOR; INTRACEREBROVENTRICULAR; DOSE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
U.D. Sohn e H.C. Choi, "DIFFERENTIAL-EFFECTS OF RANF AND CHRONIC GUANABENZ TO PRESYNAPTIC ANDPOSTSYNAPTIC ALPHA-2-ADRENOCEPTOR-MEDIATED CARDIOVASCULAR-RESPONSE INPITHED RATS", General pharmacology, 30(4), 1998, pp. 605-611

Abstract

1, In normal rats, intracerebroventricular (ICV) guanabenz induced a decrease in blood pressure (BP) and heart rate (HR), and this hypotension or bradycardia was not changed by rANF pretreatment (3 mu g ICV), 2. In pithed rats, intravenous (IV) guanabenz, an alpha 2-adrenoceptoragonist, produced an increase in mean blood pressure (MBP) in a dose-dependent manner. The presser response by guanabenz was attenuated by infusion of rANF. This attenuation was additive when incubated in combination with yohimbine. 3. In pithed rats, the presser response due tothe increase of sympathetic outflow with electrical stimulation was partially blocked by rANF infusion or chronic guanabenz treatment. Thisreduction was not augmented by chronic guanabenz plus rANF treatment,4. The inhibitory action of guanabenz in tachycardia evoked by electrical stimulation at the C7-T1 site was attenuated by rANF, but not by chronic treatment with guanabenz. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 06:12:07