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Titolo:
THE ROLE OF DOPAMINE IN THE EXPRESSION OF MORPHINE-WITHDRAWAL
Autore:
ELKADI AOS; SHARIF SI;
Indirizzi:
UNIV MONTREAL,FAC MED,DEPT PHARMACOL,CP 6128,SUCCURSALE A QUEBEC CITYPQ H3C 3J7 CANADA AL ARAB MED UNIV,FAC MED,DEPT PHARMACOL BENGHAZI LIBYA
Titolo Testata:
General pharmacology
fascicolo: 4, volume: 30, anno: 1998,
pagine: 499 - 505
SICI:
0306-3623(1998)30:4<499:TRODIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE-PRECIPITATED WITHDRAWAL; LOCUS COERULEUS NEURONS; DEPENDENT MICE; RATS; RECEPTORS; SYMPTOMS; DRUGS; MECHANISMS; CLONIDINE; PROLACTIN;
Keywords:
DEPENDENCE; DOPAMINE; MICE; MORPHINE; NALOXONE; WITHDRAWAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
A.O.S. Elkadi e S.I. Sharif, "THE ROLE OF DOPAMINE IN THE EXPRESSION OF MORPHINE-WITHDRAWAL", General pharmacology, 30(4), 1998, pp. 499-505

Abstract

1. Both L-dopa and low doses of apomorphine potentiated withdrawal symptoms such as jumping, ''wet dog'' shakes and burrows. L-dopa reducedhypothermia and potentiated body weight loss, whereas apomorphine produced opposite effects. 2. Higher doses of apomorphine attenuated jumping and burrows but had no effect on ''wet dog'' shakes. On the other hand, and with the exception of sulpiride, all other dopamine (DA) antagonists produced effects opposite those of the agonists with regard to jumping, ''wet dog'' shakes and burrows. 3. In addition, DA antagonists reduced hypothermia and body weight loss. The effects of DA agonists and antagonists were investigated in mice injected with 6-hydroxydopamine (6-OHDA) intracerebrally to examine whether DA mediated effectsare somehow linked to noradrenergic pathways. 4. Mice pretreated with6-OHDA developed a higher degree of naloxone induced withdrawal jump ing than did untreated mice. 6-OHDA reversed the effects of apomorphine on ''wet dog'' shakes and burrows while abolishing those of L-dopa on all withdrawal symptoms, the only exception being jumping, which remained unchanged. 5. 6-OHDA also reversed the effects of sulpiride on all withdrawal symptoms while reversing the effects of pimozide on jumping, and it abolished its effect on hypothermia. 6. These findings provide evidence suggesting that the effects of DA agonists and antagonists are dependent at least partly on intact noradrenergic pathways. (C)1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:47:01