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Titolo:
EFFECT OF EXERCISE TRAINING AND CHRONIC ETHANOL INGESTION ON CHOLINESTERASE ACTIVITY AND LIPID-PEROXIDATION IN BLOOD AND BRAIN-REGIONS OF RAT
Autore:
HUSAIN K; SOMANI SM;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 2, volume: 22, anno: 1998,
pagine: 411 - 423
SICI:
0278-5846(1998)22:2<411:EOETAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINESTERASE ACTIVITIES; PHYSICAL EXERCISE; ALCOHOL ACTION; RESPONSES; STRESS; SYSTEM; ACETYLTRANSFERASE; MECHANISMS; TOLERANCE; PROTEINS;
Keywords:
ACETYLCHOLINESTERASE; BRAIN REGIONS; BUTYRYLCHOLINESTERASE; ETHANOL; EXERCISE TRAINING; LIPID PEROXIDATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K. Husain e S.M. Somani, "EFFECT OF EXERCISE TRAINING AND CHRONIC ETHANOL INGESTION ON CHOLINESTERASE ACTIVITY AND LIPID-PEROXIDATION IN BLOOD AND BRAIN-REGIONS OF RAT", Progress in neuro-psychopharmacology & biological psychiatry, 22(2), 1998, pp. 411-423

Abstract

1. This study examines the effects of exercise training and chronic ethanol consumption on cholinesterase activity and its relationship to lipid peroxidation in blood and brain regions of rat. 2. Exercise training (6.5 weeks) decreased acetylcholinesterase (AChE) activity significantly (64% of control) in hypothalamus and increased AChE activity in cerebral cortex (149% of control), whereas, malondialdehyde (MDA) levels increased in hypothalamus (129% of control) and decreased in cortex, striatum, and cerebellum (50%, 69% and 75% of control), respectively. 3. Chronic ethanol ingestion (2.0 gm/kg, p.o. for 6.5 weeks) significantly increased butyrylcholinesterase (BuChE) activity in plasma (136% of control) and decreased. AChE activity in hypothalamus (63% of control), whereas, MDA levels increased in hypothalamus, cortex, and plasma (140%, 130% and 220% of control), respectively. 4. The combination significantly increased BuChE activity (173% of control) in plasma and decreased AChE activity (71% of control) in hypothalamus and (57% of control) in cerebellum, whereas, MDA levels increased in hypothalamus, cerebellum, medulla and plasma(134%, 128%, 140% and 309% of control), respectively. 5. Exercise training, chronic ethanol ingestion,and combination selectively inhibited hypothalamic AChE and the inhibition was correlated with increased lipid peroxidation (r = 0.11, 0.41 and 0.45) which may perturb hypothalamic function. The combination enhancedthe peripheral stress response by increasing plasma BuChE activity and lipid peroxidation.

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Documento generato il 05/07/20 alle ore 22:54:20