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Titolo:
A CLOSE CORRELATION BETWEEN C-ERBB-2 GENE AMPLIFICATION AND LOCAL PROGRESSION IN ENDOMETRIAL ADENOCARCINOMA
Autore:
SEKI A; NAKAMURA K; KODAMA J; MIYAGI Y; YOSHINOUCHI M; KUDO T;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT OBSTET & GYNECOL,2-5-1 SHIKATA CHO OKAYAMA 700 JAPAN OKAYAMA UNIV,SCH MED,DEPT OBSTET & GYNECOL OKAYAMA 700 JAPAN
Titolo Testata:
European journal of gynaecological oncology
fascicolo: 1, volume: 19, anno: 1998,
pagine: 90 - 92
SICI:
0392-2936(1998)19:1<90:ACCBCG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOPHAGEAL ADENOCARCINOMAS; HER-2/NEU EXPRESSION; OVER-EXPRESSION; NEU ONCOGENE; HUMAN-BREAST; CANCER; CARCINOMA; SURVIVAL; OVEREXPRESSION; EGFR;
Keywords:
C-ERBB-2; GENE AMPLIFICATION; ENDOMETRIAL ADENOCARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Seki et al., "A CLOSE CORRELATION BETWEEN C-ERBB-2 GENE AMPLIFICATION AND LOCAL PROGRESSION IN ENDOMETRIAL ADENOCARCINOMA", European journal of gynaecological oncology, 19(1), 1998, pp. 90-92

Abstract

The c-erbB-2 proto-oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity. The purpose of this study was to determine whether c-erbB-2 gene amplification measured by the simple and sensitive differential polymerase chain reaction (PCR) method correlates with clinicopathological factors in endometrial adenocarcinomas. Overall, 7 out of the 38 endometrial adenocarcinomas (18.4%) displayed amplified c-erbB-2 oncogene. No correlation between c-erbB-2 gene amplification and FIGO stage, histologic grade or existence of metastatic disease was found. There was a significant association between c-erbB-2 gene amplification and deep myometrial invasion. Inthe current study, it has been suggested that c-erbB-2 gene amplification is possibly involved in local progression but is not closely related to the loss of cell differentiation and metastasis.

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Documento generato il 01/12/20 alle ore 07:00:44