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Titolo:
DEPLETION OF OMEGA-3-FATTY-ACID LEVELS IN RED-BLOOD-CELL MEMBRANES OFDEPRESSIVE PATIENTS
Autore:
PEET M; MURPHY B; SHAY J; HORROBIN D;
Indirizzi:
UNIV SHEFFIELD,NO GEN HOSP,DEPT PSYCHIAT,HERRIES RD SHEFFIELD S5 7AU S YORKSHIRE ENGLAND EFAMOL RES INST KENTVILLE NS B4N 4H8 CANADA
Titolo Testata:
Biological psychiatry
fascicolo: 5, volume: 43, anno: 1998,
pagine: 315 - 319
SICI:
0006-3223(1998)43:5<315:DOOLIR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; IMIPRAMINE BINDING; HEART-DISEASE; YOUNG-ADULTS; FLUIDITY; CHOLESTEROL; SEROTONIN; NUTRITION; INCREASE; SMOKING;
Keywords:
DEPRESSION; POLYUNSATURATED FATTY ACIDS; DOCOSAHEXANOIC ACID; PHOSPHOLIPID; CELL MEMBRANES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M. Peet et al., "DEPLETION OF OMEGA-3-FATTY-ACID LEVELS IN RED-BLOOD-CELL MEMBRANES OFDEPRESSIVE PATIENTS", Biological psychiatry, 43(5), 1998, pp. 315-319

Abstract

Background: It has been hypothesized that depletion of cell membrane n3 polyunsaturated fatty acids (PUFA), particularly docosahexanoic acid (DHA), may be of etiological importance in depression. Methods: We measured the fatty acid composition of phospholipid in cell membranes from red blood cells (RBC) of 15 depressive patients and 15 healthy control subjects. Results: Depressive patients showed significant depletions of total n3 PUFA and particularly DHA. Incubation of RBC from control subjects with hydrogen peroxide abolished all significant differences between patients and controls. Conclusions: These findings suggestthat RBC membranes in depressive patients show evidence of oxidative damage, Possible interpretations, and implications for the etiology and treatment of depression, are discussed. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 24/01/20 alle ore 15:29:34