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Titolo:
COMPARISON OF HIGHLY PURIFIED FSH (METRODIN HIGH-PURITY) WITH PERGONAL FOR IVF SUPEROVULATION
Autore:
BAGRATEE JS; LOCKWOOD G; BERNAL AL; BARLOW DH; LEDGER WL;
Indirizzi:
JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND UNIV NATAL ZA-4001 DURBAN SOUTH AFRICA
Titolo Testata:
Journal of assisted reproduction and genetics
fascicolo: 2, volume: 15, anno: 1998,
pagine: 65 - 69
SICI:
1058-0468(1998)15:2<65:COHPF(>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; GONADOTROPIN-RELEASING-HORMONE; PITUITARY DESENSITIZATION; INVITRO FERTILIZATION; LUTEINIZING-HORMONE; CONCEPTION; PREGNANCY; OVULATION; AGONISTS;
Keywords:
GONADOTROPINS; HYPERSTIMULATION; METRODIN-HP; OVARIAN STIMULATION; PERGONAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Bagratee et al., "COMPARISON OF HIGHLY PURIFIED FSH (METRODIN HIGH-PURITY) WITH PERGONAL FOR IVF SUPEROVULATION", Journal of assisted reproduction and genetics, 15(2), 1998, pp. 65-69

Abstract

Purpose: The use of highly purified follicle-stimulating hormone (Metrodin-HP) was compared with that of a preparation containing follicle-stimulating hormone and luteinizing hormone (Pergonal) for production of superovulation in an NF program. Methods: We used the Oxford Fertility Unit database to identify patients undergoing their first cycle ofIVF, using either Metrodin-HP or Pergonal. Patients were treated witha standardized drug protocol and were stratified by age and cause of infertility, Ovarian stimulation with either Metrodin-HP (Serono Laboratories) or human menopausal gonadotropin (hMG; Pergonal; Serono Laboratories) after pituitary desensitization commenced in the midluteal phase of the preceding cycle. Monitoring was performed by ultrasound andserum estradiol measurement prior to transvaginal oocyte recovery, followed by IVF and transfer of no more than three embryos. Results: ForMetrodin-HP versus Pergonal, the rates of egg retrieval (98 vs 94%), fertilization (89 vs 92%), clinical pregnancy (32.9 vs 23.4%), miscarriage (4.1 vs 4.5%), live birth (26 vs 18.5%), and ovarian hyperstimulation syndrome (5.5% vs 5.9%) were similar in both groups. The apparentincrease in clinical pregnancy and live birth with Metrodin-HP did not reach statistical significance. The dosages of gonadotropins used were comparable, Estradiol levels measured on day 8 of stimulation were significantly lower in the Metrodin-HP group than in the Pergonal group, but the difference did not reach statistical significance on the day of hCG administration. Significantly more follicles (greater than 12mm) were obtained in the Metrodin-HP group, but the numbers of eggs recovered and fertilized were similar in the two groups. Conclusions: These findings demonstrate that highly purified FSH (Metrodin-HP) is aseffective and successful as hMG (Pergonal) for ovarian stimulation ina standard NF regimen, Exogenous luteinizing hormone (LH) is not required for satisfactory ovarian stimulation in IVF. Measurement of estradiol may be less helpful in the monitoring of Metrodin-HP cycles, but the level reached on the day of hCG administration can still be used to predict, and hence avoid, ovarian hyperstimulation syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:14:23