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Titolo:
AMPA-RECEPTOR AND KAINATE-RECEPTOR DIFFERENTIALLY MEDIATE EXCITATORY AMINO ACID-INDUCED DOPAMINE AND ACETYLCHOLINE-RELEASE FROM RAT STRIATAL SLICES
Autore:
JIN S;
Indirizzi:
NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,10 KENT RIDGE CRESCENT SINGAPORE 119260 SINGAPORE KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,SECT MOL NEUROPHARMACOL S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Neuropharmacology
fascicolo: 11-12, volume: 36, anno: 1997,
pagine: 1503 - 1510
SICI:
0028-3908(1997)36:11-12<1503:AAKDME>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; GLUTAMATE-RECEPTOR; DOMOIC ACID; CONCANAVALIN-A; IN-VIVO; CYCLOTHIAZIDE; NMDA; DESENSITIZATION; ANTAGONISTS; SUBTYPES;
Keywords:
CYCLOTHIAZIDE; CONCANAVALIN A; NON-NMDA RECEPTORS; TRANSMITTER RELEASE; NBQX; CNQX;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S. Jin, "AMPA-RECEPTOR AND KAINATE-RECEPTOR DIFFERENTIALLY MEDIATE EXCITATORY AMINO ACID-INDUCED DOPAMINE AND ACETYLCHOLINE-RELEASE FROM RAT STRIATAL SLICES", Neuropharmacology, 36(11-12), 1997, pp. 1503-1510

Abstract

Rat striatal slices, preincubated with [H-3]dopamine (DA) and [C-14]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) caused a concentration-dependent decrease in 100 mu M lpha-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA)-, 100 mu M kainate- or 100 mM glutamate-induced release of DA and ACh. The IC50 of NBQX is 3-fold higher (for ACh release)and is 2-fold lower (for DA release) than that of CNQX. This is in agreement with the IC50 ratio of NBQX and CNQX on kainate- and AMPA-receptor binding. These two antagonists, at doses that produce an equivalent blockade of kainate-receptor binding (5 mu M for NBQX and 1.56 mu Mfor CNQX), caused an approximately equal decrease in ACh but not DA-release induced by 100 mu M kainate or AMPA. At doses that produce an equivalent blockade of AMPA-receptor binding (5 mu M for NBQX and 10 muM for CNQX), they caused an approximately equal decrease in DA but not ACh release induced by 100 mu M AMPA or kainate. Moreover, concanavalin A (0.3 and 0.5 mg/ml), which selectively potentiates kainate-receptor responses, markedly enhanced 100 mu M kainate-induced release of ACh but not DA. Cyclothiazide (10 mu M), which selectively potentiates AMPA-receptor responses, significantly increased 100 mu M AMPA- or kainate-induced release of DA but not ACh. In summary, these results indicate that AMPA- and kainate-receptor activation, respectively, are predominantly involved in excitatory amino acid (EAA)induced DA and ACh release in the striatum. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:31:29