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Titolo:
IDENTIFICATION AND LOCALIZATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORSIN THE OCULAR-TISSUES OF THE CHICK
Autore:
FISCHER AJ; MCKINNON LA; NATHANSON NM; STELL WK;
Indirizzi:
UNIV CALGARY,FAC MED,DEPT ANAT,LIONS SIGHT CTR,3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 392, anno: 1998,
pagine: 273 - 284
SICI:
0021-9967(1998)392:3<273:IALOMA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC AMACRINE CELLS; RETINAL-PIGMENT EPITHELIUM; CILIARY GANGLION-CELLS; RABBIT RETINA; BINDING-PROPERTIES; BIPOLAR CELLS; HIGH-AFFINITY; NEURONS; ACETYLTRANSFERASE; MYOPIA;
Keywords:
RETINA; RETINAL PIGMENT EPITHELIUM; CHOROID; CILIARY BODY; CILIARY GANGLION; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Fischer et al., "IDENTIFICATION AND LOCALIZATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORSIN THE OCULAR-TISSUES OF THE CHICK", Journal of comparative neurology, 392(3), 1998, pp. 273-284

Abstract

The purpose of this study was to characterize the distribution of muscarinic acetylcholine receptors (mAChRs) in the ocular tissues of hatched chicks. In the chick, different isoforms of these receptors have been detected in the brain, heart, and retina, and mAChRs in ocular tissues have been implicated in the pathogenesis of form-deprivation myopia. However, the precise anatomical distribution of mAChRs within the retina, retinal pigment epithelium, choroid, ciliary body, and ciliaryganglion remains unknown. We used affinity-purified, type-specific antibodies directed to three different chick mAChR subtypes (cm2, cm3, and cm4) to detect receptor immunoreactivity in sections and extracts of these ocular tissues. We found cm2, cm3, and cm4 in the retina, retinal pigment epithelium, choroid, and ciliary body Within the retina, cm2 was expressed in numerous amacrine and ganglion cells; cm3 was expressed in many bipolar cells and small subsets of amacrine cells; and cm4 was found in most, if not all, amacrine and ganglion cells. Each mAChR was localized to distinct strata within the inner plexiform layer that cumulatively form three broad bands that closely match previouslydescribed localizations of subtype-nonspecific muscarinic ligand binding. Only cm3 was detected in the outer plexiform layer, and only cm4 was detected in the ciliary ganglion. We propose that each mAChR subtype has unique functions in each ocular tissue. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:04:40