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Titolo:
EFFECTS OF POSTNATAL ANTI-NGF ON THE DEVELOPMENT OF CGRP-IR NEURONS IN THE DORSAL-ROOT GANGLION
Autore:
TONRA JR; MENDELL LM;
Indirizzi:
SUNY STONY BROOK,DEPT PHYSIOL & BIOPHYS STONY BROOK NY 11794 SUNY STONY BROOK,DEPT PHYSIOL & BIOPHYS STONY BROOK NY 11794 SUNY STONY BROOK,DEPT NEUROBIOL & BEHAV STONY BROOK NY 11794
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 392, anno: 1998,
pagine: 489 - 498
SICI:
0021-9967(1998)392:4<489:EOPAOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; NERVE GROWTH-FACTOR; PRIMARY SENSORY NEURONS; PRIMARY AFFERENT NEURONS; SUBSTANCE-P; SPINAL-CORD; RAT SKIN; ADULT-RAT; MYELINATED NOCICEPTORS; INDUCED HYPERALGESIA;
Keywords:
DRG; PAIN; NERVE GROWTH FACTOR; NEUROTROPHIN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Tonra e L.M. Mendell, "EFFECTS OF POSTNATAL ANTI-NGF ON THE DEVELOPMENT OF CGRP-IR NEURONS IN THE DORSAL-ROOT GANGLION", Journal of comparative neurology, 392(4), 1998, pp. 489-498

Abstract

Experiments were undertaken to examine anatomical correlates of physiological effects of rabbit sera raised against nerve growth factor (anti-NGF) on nociceptive afferents. This antiserum has been shown to deplete the population of A-delta high threshold mechanoreceptors and to reduce neurogenic vasodilatation. Because numerous studies implicate calcitonin gene related peptide (CGRP)-containing sensory neurons in these effects, immunocytochemical and anatomical techniques were used toexamine the normal development of CGRP-immunoreactive (-IR) neurons in the dorsal root ganglion (DRG) of rats from 13 days to 19 weeks of age, and to compare this to the development in rats treated neonatally (postnatal days 2-14) with anti-NGF. In controls the rate of increase in the mean diameter of CGRP-IR cells was substantially greater between 13 days and 5 weeks of age than it was between 5 weeks and 19 weeks,in contrast to CGRP-negative neurons whose rate of growth remained relatively constant. Anti-NGF had no significant effect on growth rate, but rats treated with anti-NGF exhibited a reduced proportion of CGRP-IR neurons at 5 weeks. This deficit was reversed by 19 weeks unlike the physiological changes. These results indicate independent regulationof CORP expression and nociceptor physiology by NGF. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:23:15