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Titolo:
AEROSOL BOLUS DISPERSION IN PATIENTS WITH BRONCHIOLITIS OBLITERANS AFTER HEART-LUNG AND DOUBLE-LUNG TRANSPLANTATION
Autore:
BRAND P; APP EM; MEYER T; KUR F; MULLER C; DIENEMANN H; REICHART B; FRUHMANN G; HEYDER J;
Indirizzi:
GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL,ROBERT KOCH ALLEE 6 D-82131 GAUTING GERMANY UNIV MUNICH,GSF,RES CTR ENVIRONM & HLTH,INST INHALAT BIOL D-80539 MUNICH GERMANY
Titolo Testata:
Journal of aerosol medicine
fascicolo: 1, volume: 11, anno: 1998,
pagine: 41 - 53
SICI:
0894-2684(1998)11:1<41:ABDIPW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
STANDARDIZATION; VENTILATION; REJECTION; DIAGNOSIS; CURVE;
Keywords:
BRONCHIOLITIS OBLITERANS; LUNG TRANSPLANTATION; AEROSOL BOLUS DISPERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Brand et al., "AEROSOL BOLUS DISPERSION IN PATIENTS WITH BRONCHIOLITIS OBLITERANS AFTER HEART-LUNG AND DOUBLE-LUNG TRANSPLANTATION", Journal of aerosol medicine, 11(1), 1998, pp. 41-53

Abstract

Bronchiolitis obliterans (BO) is one of the main late complications in patients after lung transplantation. Because BO is located in small airways, conventional lung function tests are supposed to be rather insensitive to detect early stages of this disease, In this study, the capability of the aerosol bolus dispersion test to detect BO was testedin 12 subjects with heart-lung and double-lung transplantation. Four of these patients had histological evidence of BO, The broadening (dispersion) of inhaled boluses consisting of monodispersed inert test particles during respiration was repeatedly measured in each subject, Additional measurements of spirometric and bodyplethysmographic measurements were performed, Patients with evidence of BO showed significantly increased aerosol bolus dispersion and significantly reduced maximal airflow parameters, Calculation of receiver operating characteristics (ROCs) revealed that from all lung function parameters under consideration, aerosol bolus dispersion divided by the maximum expiratory flow rate at 50% of vital capacity (MEF50) and MEI50 had the highest sensitivity and specificity for the detection of BO, Both parameters showed asensitivity and specificity of 100%, Therefore, it may be speculated that even in early stages of disease, the combination of MEF50 measurement with aerosol bolus dispersion measurements may be a powerful toolfor the detection of BO in patients with lung transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 06:52:41