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Titolo:
ADULT RATS STRESSED AS NEONATES SHOW EXAGGERATED BEHAVIORAL-RESPONSESTO BOTH PHARMACOLOGICAL AND ENVIRONMENTAL CHALLENGES
Autore:
KEHOE P; SHOEMAKER WJ; TRIANO L; CALLAHAN M; RAPPOLT G;
Indirizzi:
TRINITY COLL,DEPT PSYCHOL HARTFORD CT 06106 UNIV CONNECTICUT,CTR HLTH,DEPT PSYCHIAT STORRS CT 06269
Titolo Testata:
Behavioral neuroscience
fascicolo: 1, volume: 112, anno: 1998,
pagine: 116 - 125
SICI:
0735-7044(1998)112:1<116:ARSANS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG PUPS; EXTRACELLULAR DOPAMINE LEVELS; MATERNAL SEPARATION; INDIVIDUAL-DIFFERENCES; INVIVO MICRODIALYSIS; FOOTSHOCK STRESS; 10-DAY-OLD RATS; INFANT RATS; AMPHETAMINE; SENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Kehoe et al., "ADULT RATS STRESSED AS NEONATES SHOW EXAGGERATED BEHAVIORAL-RESPONSESTO BOTH PHARMACOLOGICAL AND ENVIRONMENTAL CHALLENGES", Behavioral neuroscience, 112(1), 1998, pp. 116-125

Abstract

Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. Asadults, animals were given either a pharmacological challenge (1.0 or2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged.

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Documento generato il 19/01/20 alle ore 06:06:48