Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PREFRONTAL CORTEX AND CAUDATE-NUCLEUS IN CONDITIONAL ASSOCIATIVE LEARNING - DISSOCIATED EFFECTS OF SELECTIVE BRAIN-LESIONS IN RATS
Autore:
WINOCUR G; ESKES G;
Indirizzi:
BAYCREST CTR GERIATR CARE,ROTMAN RES INST,3560 BATHURST ST N YORK ON M6A 2E1 CANADA UNIV TORONTO,DEPT PSYCHOL TORONTO ON M5S 1A1 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA TRENT UNIV,DEPT PSYCHOL PETERBOROUGH ON K9J 7B8 CANADA QUEEN ELIZABETH II MED CTR,DEPT PSYCHOL HALIFAX NS CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 1, volume: 112, anno: 1998,
pagine: 89 - 101
SICI:
0735-7044(1998)112:1<89:PCACIC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTAMEN LESIONS; FUNCTIONAL DISSOCIATION; FRONTAL-CORTEX; RADIAL MAZE; MEMORY; HIPPOCAMPUS; TASKS; ACQUISITION; DEFICITS; MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
G. Winocur e G. Eskes, "PREFRONTAL CORTEX AND CAUDATE-NUCLEUS IN CONDITIONAL ASSOCIATIVE LEARNING - DISSOCIATED EFFECTS OF SELECTIVE BRAIN-LESIONS IN RATS", Behavioral neuroscience, 112(1), 1998, pp. 89-101

Abstract

Rats with lesions to prefrontal cortex (PFC) or caudate nucleus (CN) were compared on tests of conditional associative learning (GAL) that placed varying demands on conditional rule learning and working-with-memory operations that are essential for response selection. Damage to either structure impaired performance, but the respective deficits resulted from disruption of different processes. CN lesions produced a consistent learning deficit that was thought to reflect a basic impairment in forming stimulus-response (S-R) associations. The behavior of PFC rats was more Variable and depended on task requirements. When S-R learning or response selection was relatively easy, the PFC was not critical. However, when either component was made more difficult, thus requiring the contribution of strategic processes, PFC damage produced profound impairments. In addition to clarifying the roles of the PFC and CN in GAL, the results provide further evidence that multiple brain regions participate in relatively simple behavioral tasks and that their respective contributions can be dissociated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 02:49:57