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Titolo:
STRUCTURE OF THE SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO
Autore:
CHERFILS J; MENETREY J; MATHIEU M; LABRAS G; ROBINEAU S; BERAUDDUFOUR S; ANTONNY B; CHARDIN P;
Indirizzi:
CNRS,UPR 9063,LAB ENZYMOL & BIOCHIM STRUCT F-91198 GIF SUR YVETTE FRANCE CNRS,UPR 411,INST PHARMACOL MOL & CELLULAIRE F-06560 VALBONNE FRANCE
Titolo Testata:
Nature
fascicolo: 6671, volume: 392, anno: 1998,
pagine: 101 - 105
SICI:
0028-0836(1998)392:6671<101:SOTSDO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE EXCHANGE; GDP; PROTEIN; RESIDUES; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J. Cherfils et al., "STRUCTURE OF THE SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO", Nature, 392(6671), 1998, pp. 101-105

Abstract

Small G proteins switch from a resting, GDP-bound state to an active,GTP-bound state. As spontaneous GDP release is slow, guanine-nucleotide-exchange factors (GEFs) are required to promote fast activation of small G proteins through replacement of GDP with GTP in vivo(1). Families of GEFs with no sequence similarity to other GEF families have nowbeen assigned to most families of small G proteins. In the case of the small G protein Arf1, the exchange of bound GDP for GTP promotes thecoating of secretory vesicles in Golgi traffic(2). An exchange factorfor human Arf1, ARNO(3), and two closely related proteins, named cytohesin 1 (ref. 4) and GPS1 (ref. 5), have been identified. These three proteins are modular proteins with an amino-terminal coiled-coil, a Central Sec7-like domain and a carboxy-terminal pleckstrin homolog domain. The Sec7 domain contains the exchange-factor activity(3). It was first found in Sec7, a yeast protein and is present in several other proteins, including the yeast exchange factors for Arf, Gea1 and Gea2 (refs 7-9). Here we report the crystal structure of the Sec7 domain of human ARNO at 2 Angstrom resolution and the identification of the site of interaction of ARNO with Arf.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:28:11