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Titolo:
CENTROMERES, CHECKPOINTS AND CHROMATID COHESION
Autore:
ALLSHIRE RC;
Indirizzi:
WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,CREWE RD EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND
Titolo Testata:
Current opinion in genetics & development
fascicolo: 2, volume: 7, anno: 1997,
pagine: 264 - 273
SICI:
0959-437X(1997)7:2<264:CCACC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DETECTABLE ALPHA-SATELLITE; FISSION YEAST CENTROMERES; CELL-CYCLE ARREST; BUDDING YEAST; SACCHAROMYCES-CEREVISIAE; METAPHASE ARREST; PROTEIN; MITOSIS; UBIQUITIN; ANAPHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Allshire, "CENTROMERES, CHECKPOINTS AND CHROMATID COHESION", Current opinion in genetics & development, 7(2), 1997, pp. 264-273

Abstract

An emerging view is that the formation of active centromeres is modulated in an epigenetic manner reflecting the association of centromereswith heterochromatin. Support for this comes from studies on fission yeast centromeres, the properties of human neocentromeres and dicentric chromosomes, and analyses of Drosophila minichromosome deletion derivatives. A link has been established between tension across kinetochores and the phosphorylation status of kinetochore components. Vertebrate homologues of yeast MAD2 have recently been isolated and localized to kinetochores, indicating that components of the spindle integrity checkpoint are conserved. The linkage between sister chromatids is only dissolved at anaphase during mitotic and meiotic divisions. Phenotypicand localization data combined with their pattern of rapid degradation at anaphase have implicated several yeast and Drosophila proteins inaspects of sister chromatid cohesion.

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Documento generato il 29/11/20 alle ore 06:52:04