Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TO BE LEAN OR NOT TO BE LEAN - IS LEPTIN THE ANSWER
Autore:
STEPHENS TW; CARO JF;
Indirizzi:
LILLY CORP CTR,LILLY RES LABS,N AMER REGULATORY AFFAIRS,DROP CODE 2543 INDIANAPOLIS IN 46285
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 1, volume: 106, anno: 1998,
pagine: 1 - 15
SICI:
0947-7349(1998)106:1<1:TBLONT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-EXPRESSION; WHITE ADIPOSE-TISSUE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ISOLATED RAT ADIPOCYTES; BODY-WEIGHT REGULATION; BINDING PROTEIN-ALPHA; OB MESSENGER-RNA; FATTY FA/FA RAT; NEUROPEPTIDE-Y; FOOD-INTAKE;
Keywords:
LEPTIN; LEPTIN RECEPTOR; OBESITY; OBESITY THERAPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
161
Recensione:
Indirizzi per estratti:
Citazione:
T.W. Stephens e J.F. Caro, "TO BE LEAN OR NOT TO BE LEAN - IS LEPTIN THE ANSWER", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 106(1), 1998, pp. 1-15

Abstract

Leptin and the leptin receptor genes have been identified as the siteof mutations in the peripheral adipocyte hormone pathway responsible for obesity in the ob/ob mouse (Zhang et al., 1994) and the db/db mouse (Chen et al., 1996). In obese humans, ob/ob like mutations in leptinare rare but confirm a role for leptin (Montague et al., 1997), and db/db like mutations in the leptin receptor have not been found (Considine et al., 1996a); however, the increased understanding of the molecular basis for obesity has generated tremendous interest among scientists and patients alike. The new knowledge could be the base for intelligent drugs for the treatment of obesity. Herein we will put in perspective a) the physiological background that led to the discovery of leptin, b) leptin biosynthesis, c) leptin action and d) the clinical issues related to leptin as a drug for the treatment of obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:08:24