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Titolo:
IN-VIVO TUMORICIDAL EFFECT OF T-LYMPHOCYTES ACTIVATED BY LIPOSOMES CONTAINING ADRIAMYCIN ON CHEMICALLY-INDUCED RAT MALIGNANT FIBROUS HISTIOCYTOMA
Autore:
YAKUSHIJI T; YONEMURA K; NISHIDA K; TAKAGI K;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DEPT ORTHOPAED SURG,1-1-1 HONJO KUMAMOTO 860 JAPAN
Titolo Testata:
Anticancer research
fascicolo: 6D, volume: 17, anno: 1997,
pagine: 4347 - 4354
SICI:
0250-7005(1997)17:6D<4347:ITEOTA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOGENEIC-TUMOR CELLS; MEDIATED CYTO-TOXICITY; ADMINISTERED LIPOSOMES; MONOCLONAL-ANTIBODIES; INDUCED AUGMENTATION; DISTANT SITE; MACROPHAGES; ANTIGENS; MICE; INTERLEUKIN-2;
Keywords:
CYTOTOXIC T LYMPHOCYTE; LIPOSOMES; ADRIAMYCIN; MALIGNANT FIBROUS HISTIOCYTOMA; DOUBLE GRAFTED TUMOR SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
T. Yakushiji et al., "IN-VIVO TUMORICIDAL EFFECT OF T-LYMPHOCYTES ACTIVATED BY LIPOSOMES CONTAINING ADRIAMYCIN ON CHEMICALLY-INDUCED RAT MALIGNANT FIBROUS HISTIOCYTOMA", Anticancer research, 17(6D), 1997, pp. 4347-4354

Abstract

The augmentative effect of liposomes containing adriamycin (LADM) in the host-tumour immune mechanism was assessed using 9,10-dimethyl-1,2-benzanthracene induced rat malignant fibrous histiocytoma (MFH). The antitumour effect of LADM was analyzed using a double grafted tumour system in which F344 rats first received simultaneous s.c. inoculations of MFH cells in both right and left flanks and were then injected with0.2mg of LADM into the right tumour on Day 10, 12, and 14. The growthof a remote, non-treated tumour was strongly inhibited and the infiltration of CD8(+) or. CD4(+) cells at the tumour periphery was histologically revealed. This inhibition was not observed in F344 nu/nu athymic rats. Winn neutralizing assay with T cell-rich splenic lymphocytes from each drug-treated MFH-bearing rat showed that complete regression of the tumour at a low effector/target ratio occurred only in the LADM-treated group. Furthermore, the tumouricidal effects were demonstrated in coexistence with CD8(+) cells and CD4(+) cells by assay with FAGSsorting splenic lymphocytes. These results strongly suggest that intratumoural administration of LADM caused the systemic augmentation of the MFH-bearing host immune mechanism, and that the augmented response after LADM treatment was induced by the cytotoxic CD8(+) lymphocytes dependent on the CD4(+) lymphocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:02:28