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Titolo:
NCAM-180 KNOCKOUT MICE DISPLAY INCREASED LATERAL VENTRICLE SIZE AND REDUCED PREPULSE INHIBITION OF STARTLE
Autore:
WOOD GK; TOMASIEWICZ H; RUTISHAUSER U; MAGNUSON T; QUIRION R; ROCHFORD J; SRIVASTAVA LK;
Indirizzi:
MCGILL UNIV,DOUGLAS HOSP RES CTR,DEPT PSYCHIAT,LASALLE BLVD MONTREAL PQ H4H 1R3 CANADA MCGILL UNIV,DOUGLAS HOSP RES CTR,DEPT PSYCHIAT MONTREAL PQ H4H 1R3 CANADA MCGILL UNIV,DOUGLAS HOSP RES CTR,DEPT NEUROL MONTREAL PQ H4H 1R3 CANADA MCGILL UNIV,DOUGLAS HOSP RES CTR,DEPT NEUROSURG MONTREAL PQ H4H 1R3 CANADA CASE WESTERN RESERVE UNIV,DEPT GENET CLEVELAND OH 44106 EMORY UNIV,DEPT ANAT & CELL BIOL ATLANTA GA 30322
Titolo Testata:
NeuroReport
fascicolo: 3, volume: 9, anno: 1998,
pagine: 461 - 466
SICI:
0959-4965(1998)9:3<461:NKMDIL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; CENTRAL-NERVOUS-SYSTEM; SCHIZOPHRENIC-PATIENTS; CORTEX; BRAINS; RATS;
Keywords:
ANIMAL MODEL; DOPAMINE; KNOCKOUT MICE; LATERAL VENTRICLE; NEURAL CELL ADHESION MOLECULE; NEURODEVELOPMENT; PREPULSE INHIBITION; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.K. Wood et al., "NCAM-180 KNOCKOUT MICE DISPLAY INCREASED LATERAL VENTRICLE SIZE AND REDUCED PREPULSE INHIBITION OF STARTLE", NeuroReport, 9(3), 1998, pp. 461-466

Abstract

NCAM-180 knockout mice, which have documented deficits in neural migration, were used to determine whether developmental abnormalities could lead to morphological changes and alterations in sensory motor gating mechanisms. Measurement of the lateral ventricle showed that NCAM-180(-/-) mice had marked increases in both the left and right anterior horns of the lateral ventricle. Furthermore, these mice also displayed a reduction of prepulse inhibition that was differentially affected bythe dopamine agonist apomorphine. These results are discussed in light of the known increase in lateral ventricle size and reduction in prepulse inhibition that are seen in schizophrenia. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:13:00