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Titolo:
THERAPY OF MALIGNANT BRAIN-TUMORS BY INTRATUMORAL IMPLANTATION OF RETROVIRAL VECTOR-PRODUCING CELLS
Autore:
RAM Z; CULVER KW; OSHIRO EM; VIOLA JJ; DEVROOM HL; OTTO E; LONG ZF; CHIANG Y; MCGARRITY GEJ; MUUL LM; KATZ D; BLAESE RM; OLDFIELD EH;
Indirizzi:
NINCDS,SURG NEUROL BRANCH,BLDG 36,RM 4D04,10-5D37,10 CTR DR BETHESDA MD 20892 NINCDS,SURG NEUROL BRANCH BETHESDA MD 20892 NCI,METAB BRANCH BETHESDA MD 20892 GENET THERAPY INC GAITHERSBURG MD 00000 NATL CTR HUMAN GENOME RES,CLIN GENE THERAPY BRANCH BETHESDA MD 20892 NINCDS,OFF CLIN DIRECTOR BETHESDA MD 20892 NINCDS,PATHOL LAB BETHESDA MD 20892
Titolo Testata:
Nature medicine
fascicolo: 12, volume: 3, anno: 1997,
pagine: 1354 - 1361
SICI:
1078-8956(1997)3:12<1354:TOMBBI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENE; EXPERIMENTAL GLIOMAS; RAT-BRAIN; IN-VIVO; TRANSDUCTION; REGRESSION; GANCICLOVIR; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Z. Ram et al., "THERAPY OF MALIGNANT BRAIN-TUMORS BY INTRATUMORAL IMPLANTATION OF RETROVIRAL VECTOR-PRODUCING CELLS", Nature medicine, 3(12), 1997, pp. 1354-1361

Abstract

Intratumoral implantation of murine cells modified to produce retroviral vectors containing the herpes simplex virus-thymidine kinase (HSV-TK) gene induces regression of experimental brain tumors in rodents after ganciclovir (GCV) administration. We evaluated this approach in 15patients with progressive growth of recurrent malignant brain tumors. Antitumor activity was detected in five of the smaller tumors (1.4 +/- 0.5 ml). In situ hybridization for HSV-TK demonstrated survival of vector-producing cells (VPCs) at 7 days but indicated limited gene transfer to tumors, suggesting that indirect, ''bystander,'' mechanisms provide local antitumor activity in human tumors. However, the response of only very small tumors in which a high density of vector-producing cells had been placed suggests that techniques to improve delivery anddistribution of the therapeutic gene will need to be developed if clinical utility is to be achieved with this approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:25:38