Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIBODIES TO OX-40 (CD134) CAN IDENTIFY AND ELIMINATE AUTOREACTIVE T-CELLS - IMPLICATIONS FOR HUMAN AUTOIMMUNE-DISEASE
Autore:
WEINBERG AD;
Indirizzi:
PROVIDENCE PORTLAND MED CTR,EARLE A CHILES RES INST,LAB BASIC IMMUNOL,4805 NE GLISAN PORTLAND OR 97213
Titolo Testata:
Molecular medicine today
fascicolo: 2, volume: 4, anno: 1998,
pagine: 76 - 83
SICI:
1357-4310(1998)4:2<76:ATO(CI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; RECEPTOR FAMILIES; HELPER-CELLS; SPINAL-CORD; OX40 LIGAND; LEWIS RATS; MURINE; BETA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Weinberg, "ANTIBODIES TO OX-40 (CD134) CAN IDENTIFY AND ELIMINATE AUTOREACTIVE T-CELLS - IMPLICATIONS FOR HUMAN AUTOIMMUNE-DISEASE", Molecular medicine today, 4(2), 1998, pp. 76-83

Abstract

Autoantigen specific CD4(+) T cells have been implicated as the causative cell type in: multiple sclerosis, rheumatoid arthritis, autoimmune uveitis, diabetes mellitus, inflammatory bowel disease and graft-versus-host disease. The pathology of a number of experimentally induced autoimmune diseases is also mediated by autoantigen-specific CD4(+) T cells. Ideally, treatment of CD4(+) T-cell mediated diseases would eliminate the autoantigen-specific cells, while sparing the remainder of the T-cell repertoire. We have developed an effective therapy that deletes the autoreactive T cells at the site of autoimmune tissue destruction. This approach uses an antibody directed against a cell-surface protein (OX-40, also known as CD134) that is selectively upregulated onactivated autoantigen-specific T cells within the inflamed tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:05:42