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Titolo:
A RANDOMIZED, BLINDED, COMPARATIVE TRIAL OF ONE PEPSIN-DIGESTED AND 2WHOLE IGG ANTIVENOMS FOR BOTHROPS SNAKE BITES IN URABA, COLOMBIA
Autore:
OTEROPATINO R; CARDOSO JLC; HIGASHI HG; NUNEZ V; DIAZ A; TORO MF; GARCIA ME; SIERRA A; GARCIA LF; MORENO AM; MEDINA MC; CASTANEDA N; SILVADIAZ JF; MURCIA M; CARDENAS SY; DASILVA WDD;
Indirizzi:
UNIV ANTIOQUIA,FAC MED,CTR INVEST MED,PROGRAMA OFIDISMO MEDELLIN AA 1226 COLOMBIA UNIV ANTIOQUIA,FAC MED,DEPT PEDIAT MEDELLIN AA 1226 COLOMBIA INST BUTANTAN SAO PAULO BRAZIL HOSP MARIA AUXILIADORA CHIGORODO COLOMBIA HOSP LOCAL UNGUA UNGUIA COLOMBIA HOSP ANNUCIAC MUTATA COLOMBIA HOSP REG ANTONIO ROLDAN BETANCUR APARTADO COLOMBIA
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 2, volume: 58, anno: 1998,
pagine: 183 - 189
SICI:
0002-9637(1998)58:2<183:ARBCTO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENOM; SERA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Oteropatino et al., "A RANDOMIZED, BLINDED, COMPARATIVE TRIAL OF ONE PEPSIN-DIGESTED AND 2WHOLE IGG ANTIVENOMS FOR BOTHROPS SNAKE BITES IN URABA, COLOMBIA", The American journal of tropical medicine and hygiene, 58(2), 1998, pp. 183-189

Abstract

The therapeutic efficacy and the incidence of early antivenom reactions (EARs) were compared in a clinical trial performed in 79 patients bitten by Bothrops sp. in Uraba, Colombia. Patients were randomized into three groups according to the antivenom administered: A (n = 30, Butantan polyspecific, pepsin-digested Bothrops antivenom); B (n = 27, Butantan polyspecific, whole IgG Bothrops antivenom); and C (n = 22, Colombian commercial, monovalent, whole IgG Bothrops antivenom). The groups were comparable in all clinical and epidemiologic aspects; 33 patients had mild, 22 moderate, and 24 severe envenoming. At the doses used(two, four, and six vials [10 ml/vial] for mild, moderate, and severeenvenomings, respectively) there were no differences between the antivenoms in restoring normal hemostatic parameters within 24 hr. The evolution of local envenoming was comparable in the three groups. Serum venom/antivenom kinetics determined by ELISA showed a complete clearance of venom levels 1 hr after treatment in mild/moderate envenomings. In severe cases, venom levels remained detectable up to 24 hr and recurrence of antigenemia was observed in some cases. Antivenom concentrations remained at high levels up to 24 hr of treatment. The incidence ofEARs was significantly different in the groups: A (36.7%), B (11.1.%), and C (81.8%). There were no life-threatening anaphylactic reactions. We conclude that the efficacy of the three antivenoms was similar inneutralizing human Bothrops envenomings and that the production of whole IgG antivenoms by caprylic acid fractionation is a good alternative for reducing the incidence of EARs.

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Documento generato il 27/11/20 alle ore 15:55:34