Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIINFLAMMATORY EFFECTS OF ENTERICALLY COATED AMOXICILLIN-CLAVULANICACID IN ACTIVE ULCERATIVE-COLITIS
Autore:
CASELLAS F; BORRUEL N; PAPO M; GUARNER F; ANTOLIN M; VIDELA S; MALAGELADA JR;
Indirizzi:
HOSP GEN VALLE HEBRON,DIGEST SYST RES UNIT,PSO HEBRON 119 BARCELONA 08035 SPAIN
Titolo Testata:
Inflammatory bowel diseases
fascicolo: 1, volume: 4, anno: 1998,
pagine: 1 - 5
SICI:
1078-0998(1998)4:1<1:AEOECA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; INFLAMMATORY BOWEL-DISEASE; IMMUNOGLOBULIN-G; CROHNS-DISEASE; RECTAL MUCOSA; MICROFLORA; ANTIBODIES; PROTEIN; CELLS; COLON;
Keywords:
AMOXICILLIN; CLAVULANIC ACID; ANTIBIOTICS; ULCERATIVE COLITIS; TREATMENT; COLONIC INTERLEUKIN 8; ANTIINFLAMMATORY; H-2 BREATH TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F. Casellas et al., "ANTIINFLAMMATORY EFFECTS OF ENTERICALLY COATED AMOXICILLIN-CLAVULANICACID IN ACTIVE ULCERATIVE-COLITIS", Inflammatory bowel diseases, 4(1), 1998, pp. 1-5

Abstract

The inflammatory activity of colonic mucosal lesions may be stimulated by intraluminal bacteria. Our aim was to investigate whether administration of broad-spectrum antibiotics decreases inflammatory activity in ulcerative colitis. To this end, we performed a randomized, 5-day study with either oral enterically coated amoxicillin-clavulanic acid (1 g + 250 mg, t.i.d.); i.v. methylprednisolone (40 mg/day) and oral placebo (t.i.d.); or both i.v. methylprednisolone and oral amoxicillin-clavulanic acid as above, in 30 patients with clinically active ulcerative colitis. Before and after 5 days of treatment, intestinal inflammation was assessed by the quantification of mucosal release of eicosanoids and interleukin-8 by rectal dialysis in each patient. Breath H-2 excretion after oral lactulose was determined as an index of metabolic activity of colonic flora. The total release of (IL-8) interleukin-8 and eicosanoids significantly decreased in patients treated with antibiotic or steroids and antibiotic. Antibiotic treatment, but not steroids, markedly inhibited breath H-2 excretion. In conclusion, shortterm treatment with enteric-coated amoxicillin-clavulanic acid decreases theintraluminal release of IL-8 and other inflammatory mediators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:46:16