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Titolo:
CENTRAL-NERVOUS-SYSTEM COMPLICATIONS AFTER LUNG TRANSPLANTATION
Autore:
GOLDSTEIN LS; HAUG MT; PERL J; PERL MK; MAURER JR; ARROLIGA AC; MEHTA AC; KIRBY T; HIGGINS B; STILLWELL PC;
Indirizzi:
CHILDRENS HOSP SAN DIEGO,3020 CHILDRENS WAY,MC 5070 SAN DIEGO CA 92123 CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE CLEVELAND OH 44195
Titolo Testata:
The Journal of heart and lung transplantation
fascicolo: 2, volume: 17, anno: 1998,
pagine: 185 - 191
SICI:
1053-2498(1998)17:2<185:CCALT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOSPORINE-A; NEUROLOGICAL COMPLICATIONS; INFECTIOUS COMPLICATIONS; LIVER-TRANSPLANTATION; CENTRAL NEUROTOXICITY; TOXICITY; RECIPIENTS; METHYLPREDNISOLONE; CONVULSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Goldstein et al., "CENTRAL-NERVOUS-SYSTEM COMPLICATIONS AFTER LUNG TRANSPLANTATION", The Journal of heart and lung transplantation, 17(2), 1998, pp. 185-191

Abstract

Purpose: This study describes the central nervous system (CNS) eventsafter lung transplantation. Methods: A chart review of all lung transplant recipients (LTR) to collect the clinical and neuroimaging data for CNS events defined as seizures, severe headaches, confusion, or stroke. Results: Twenty-six patients of 100 LTRs from 1990 through 1995 had a CNS event; more than one event occurred in 5 patients for a totalof 32 events. Severe headache was most common, occurring in 14 patients, followed by seizures in 10, stroke in 5, and confusion in 3. The CNS event was related to infection in three of the 26 patients. Of all evaluations performed, magnetic resonance imaging (MRI) identified themost abnormalities, the most common being white matter changes consistent with cyclosporine toxicity. Cyclosporine levels were elevated in slightly more than half of the patients. Hypomagnesemia was present inthree of 10 patients with seizures. Prognosis for recovery from thesecomplications was good, with only five patients having ongoing problems with headaches, one requiring long term anticonvulsant therapy, three having minor or no limitations from stroke and no long-term problems with confusion. One patient with seizures resulting from an aspergilloma died. Conclusion: CNS events occur commonly in LTRs, mostly related to cyclosporine toxicity or infection. MRI identifies more abnormalities than computed tomography. These events were not consistently associated with documented high cyclosporine levels and hypomagnesemia. In spite of significantly abnormal MRIs, the functional outcome is favorable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:25:22