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Titolo:
NEUROTOXICOLOGIC EXAMINATION OF RATS EXPOSED TO 1,1,2,2-TETRACHLOROETHYLENE (PERCHLOROETHYLENE) VAPOR FOR 13 WEEKS
Autore:
MATTSSON JL; ALBEE RR; YANO BL; BRADLEY GJ; SPENCER PJ;
Indirizzi:
DOW CHEM CO USA,HLTH & ENVIRONM RES LABS,1803 BLDG MIDLAND MI 48674
Titolo Testata:
Neurotoxicology and teratology
fascicolo: 1, volume: 20, anno: 1998,
pagine: 83 - 98
SICI:
0892-0362(1998)20:1<83:NEORET>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY-EVOKED-POTENTIALS; CARBON-DISULFIDE; FLASH;
Keywords:
RATS; 1,1,2,2-TETRACHLOROETHYLENE; PERCHLOROETHYLENE; SUBCHRONIC EXPOSURE; EVOKED POTENTIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Mattsson et al., "NEUROTOXICOLOGIC EXAMINATION OF RATS EXPOSED TO 1,1,2,2-TETRACHLOROETHYLENE (PERCHLOROETHYLENE) VAPOR FOR 13 WEEKS", Neurotoxicology and teratology, 20(1), 1998, pp. 83-98

Abstract

Large evoked potential and EEG changes occurred in a pilot study in Fischer 344 rats during exposure to 800 ppm of 1,1,2,2-tetrachloroethylene [perchloroethylene (Perc)], a cleaning solvent with anesthetic properties. In the main study, rats were evaluated for persistent nervoussystem effects the week following exposure to 0, 50, 200, or 800 ppm Perc for 6 h/day, 5 days/week, for 13 weeks. The only effect related to treatment was in the flash evoked potential (FEP-V), recorded from the visual cortex. The longer latency potentials (N-3) of the FEP-V hada greater amplitude in the 800 ppm Perc group. The FEP-Vs were of normal shape and latency. Although mild neurotoxicity could not be ruled out completely, amplitude changes in N-3 can occur for a variety of psychophysiological reasons other than neurotoxicity. Consequently, as astand-alone finding, the toxicologic significance of the larger FEP in the 800 ppm exposure group was unknown. Other data did not support adiagnosis of neurotoxicity. No treatment-related alterations were noted in expanded clinical observations, in the FEP recorded from the cerebellum (as opposed to visual cortex FEP-V), or in auditory, somatosensory, or caudal nerve evoked potentials. No treatment-related lesions were noted during histopathologic examination of eyes, optic nerves, optic tract, or multiple sections of brain, spinal cord, peripheral nerves, or limb muscles. The no-observed-effect-level (NOEL) was 200 ppm,based on increased amplitude of the longer latency potentials of the FEP at 800 ppm. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:08:16