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Titolo:
COMUTAGENESIS-V - RAPID CONVERSION OF 2-HYDROXYLAMINO-3-METHYLPYRIDINE TO 2-AMINO-3-METHYLPYRIDINE BY A HEPATIC S9 PREPARATION
Autore:
GORROD JW; ALTUNTAS TG;
Indirizzi:
UNIV ESSEX,JOHN TABOR LABS,TOXICOL UNIT,WIVENHOE PK COLCHESTER CO4 3SQ ESSEX ENGLAND UNIV LONDON KINGS COLL,CHELSEA DEPT PHARM LONDON ENGLAND
Titolo Testata:
European journal of drug metabolism and pharmacokinetics
fascicolo: 4, volume: 22, anno: 1997,
pagine: 341 - 344
SICI:
0378-7966(1997)22:4<341:C-RCO2>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLISM;
Keywords:
IN VITRO METABOLISM; 2-HYDROXYLAMINO-3-METHYLPYRIDINE; 2-AMINO-3-METHYLPYRIDINE; ENZYMATIC REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Gorrod e T.G. Altuntas, "COMUTAGENESIS-V - RAPID CONVERSION OF 2-HYDROXYLAMINO-3-METHYLPYRIDINE TO 2-AMINO-3-METHYLPYRIDINE BY A HEPATIC S9 PREPARATION", European journal of drug metabolism and pharmacokinetics, 22(4), 1997, pp. 341-344

Abstract

The in vitro metabolism of 2-hydroxylamino-3-methylpyridine has been investigated using arochlor 1254 pretreated rat S9 mixtures. 2-Hydroxylamino-3-methylpyridine is rapidly converted to the parent amine 2-amino-3-methylpyridine. No further oxidation products of 2-hydroxylamino-3-methylpyridine (i.e., nitroso or nitro) were detected under the HPLCconditions used. This observation may explain our previous findings on the in vitro metabolism of 2-amino-3-methylpyridine where no hydroxylamino metabolite was detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 13:51:36